AIMC Topic: Recombinant Proteins
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Generating functional protein variants with variational autoencoders.
PLoS computational biology
Feb 26, 2021
The vast expansion of protein sequence databases provides an opportunity for new protein design approaches which seek to learn the sequence-function relationship directly from natural sequence variation. Deep generative models trained on protein sequ...
Application of machine learning methods to pathogen safety evaluation in biological manufacturing processes.
Biotechnology progress
Feb 24, 2021
The production of recombinant therapeutic proteins from animal or human cell lines entails the risk of endogenous viral contamination from cell substrates and adventitious agents from raw materials and environment. One of the approaches to control su...
Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.
Scientific reports
Feb 9, 2021
Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore li...
Prognostic Value of Serum Thyroglobulin Measured at 48 Hours Versus 72 Hours after Second Dose of Recombinant Human Thyrotropin in Surveillance of Well-Differentiated Thyroid Cancer.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Dec 15, 2020
OBJECTIVE: The sensitivity of thyroglobulin (Tg) to detect differentiated thyroid cancer recurrence increases with the rise of the thyrotropin level. Since 1998, recombinant human thyrotropin (rhTSH) has been commercially available for this purpose. ...
Codon optimization with deep learning to enhance protein expression.
Scientific reports
Oct 19, 2020
Heterologous expression is the main approach for recombinant protein production ingenetic synthesis, for which codon optimization is necessary. The existing optimization methods are based on biological indexes. In this paper, we propose a novel codon...
Single-cell dispensing and 'real-time' cell classification using convolutional neural networks for higher efficiency in single-cell cloning.
Scientific reports
Jan 27, 2020
Single-cell dispensing for automated cell isolation of individual cells has gained increased attention in the biopharmaceutical industry, mainly for production of clonal cell lines. Here, machine learning for classification of cell images is applied ...
High-level expression of Thermobifida fusca glucose isomerase for high fructose corn syrup biosynthesis.
Enzyme and microbial technology
Dec 13, 2019
Glucose isomerase (GIase), an efficient enzyme in the isomerization of d-glucose to d-fructose, has been widely used in food processing. In this study, an efficient expression system for a Thermobifida fusca GIase (GIase) in Escherichia coli was firs...
Accurate and cost-effective prediction of HBsAg titer in industrial scale fermentation process of recombinant Pichia pastoris by using neural network based soft sensor.
Biotechnology and applied biochemistry
Jun 24, 2019
In the current work, the attempt was made to apply best-fitted artificial neural network (ANN) architecture and the respective training process for predicting final titer of hepatitis B surface antigen (HBsAg), produced intracellularly by recombinant...
Application of recurrent neural network for online prediction of cell density of recombinant Pichia pastoris producing HBsAg.
Preparative biochemistry & biotechnology
Feb 1, 2019
Artificial neural networking (ANN) seems to be a promising soft sensor for implementing current approaches of quality by design (QbD) and process analytical technologies (PAT) in the biopharmaceutical industry. In this study, we aimed to implement be...
In vitro survival, growth, and maturation of sheep oocytes from secondary follicles cultured in serum-free conditions: impact of a constant or a sequential medium containing recombinant human FSH.
Domestic animal endocrinology
Dec 18, 2018
This study evaluated the in vitro development and maturation of ovine oocytes from secondary follicles cultured in serum-free medium containing fixed or sequential concentrations of recombinant human FSH (rhFSH). Follicles were cultured in α-MEM alon...
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