AIMC Topic: rhoA GTP-Binding Protein

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Butyric acid alleviates LPS-induced intestinal mucosal barrier damage by inhibiting the RhoA/ROCK2/MLCK signaling pathway in Caco2 cells.

PloS one Dec 26, 2024
Butyric acid (BA) can potentially enhance the function of the intestinal barrier. However, the mechanisms by which BA protects the intestinal mucosal barrier remain to be elucidated. Given that the Ras homolog gene family, member A (RhoA)/Rho-associa...
Humans Signal Transduction Lipopolysaccharides Caco-2 Cells rho-Associated Kinases Myosin-Light-Chain Kinase rhoA GTP-Binding Protein Intestinal Mucosa Butyric Acid Occludin Zonula Occludens-1 Protein Pyridines Amides
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Spatial and temporal dynamics of RhoA activities of single breast tumor cells in a 3D environment revealed by a machine learning-assisted FRET technique.

Experimental cell research Nov 20, 2021
One of the hallmarks of cancer cells is their exceptional ability to migrate within the extracellular matrix (ECM) for gaining access to the circulatory system, a critical step of cancer metastasis. RhoA, a small GTPase, is known to be a key molecula...
Humans Machine Learning Female Breast Neoplasms Animals Time Factors Cell Line, Tumor Rats Cell Movement rhoA GTP-Binding Protein Fluorescence Resonance Energy Transfer Collagen Cell Shape Cell Polarity
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Humans Time Factors Cell Proliferation Signal Transduction Cell Movement Dose-Response Relationship, Drug Receptors, G-Protein-Coupled rho-Associated Kinases rhoA GTP-Binding Protein Muscle, Smooth, Vascular Thiazolidines Hydrazones Thiourea HEK293 Cells Myocytes, Smooth Muscle Endothelial Cells Actin Cytoskeleton Aminosalicylic Acids Naphthols Purinones Saphenous Vein
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