AIMC Topic: rho-Associated Kinases

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Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis.

Arthritis research & therapy Apr 11, 2025
BACKGROUND: The modified Rodnan skin score (mRSS), a measure of systemic sclerosis (SSc) skin thickness, is agnostic to inflammation and vasculopathy. Previously, we demonstrated the potential of neural network-based digital pathology applied to SSc ...
Middle Aged Treatment Outcome Male Skin Scleroderma, Systemic Biopsy rho-Associated Kinases Neural Networks, Computer Adult Female Humans
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Butyric acid alleviates LPS-induced intestinal mucosal barrier damage by inhibiting the RhoA/ROCK2/MLCK signaling pathway in Caco2 cells.

PloS one Dec 26, 2024
Butyric acid (BA) can potentially enhance the function of the intestinal barrier. However, the mechanisms by which BA protects the intestinal mucosal barrier remain to be elucidated. Given that the Ras homolog gene family, member A (RhoA)/Rho-associa...
Intestinal Mucosa Butyric Acid Caco-2 Cells rhoA GTP-Binding Protein Myosin-Light-Chain Kinase Zonula Occludens-1 Protein Signal Transduction Amides Occludin rho-Associated Kinases Pyridines Lipopolysaccharides Humans
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QSAR modelling using combined simple competitive learning networks and RBF neural networks.

SAR and QSAR in environmental research Jan 26, 2018
The aim of this study was to propose a QSAR modelling approach based on the combination of simple competitive learning (SCL) networks with radial basis function (RBF) neural networks for predicting the biological activity of chemical compounds. The p...
Neural Networks, Computer rho-Associated Kinases Models, Molecular Phenols Machine Learning Protein Kinase Inhibitors Quantitative Structure-Activity Relationship
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Saphenous Vein Purinones Actin Cytoskeleton Naphthols Aminosalicylic Acids Myocytes, Smooth Muscle Endothelial Cells HEK293 Cells Signal Transduction Thiazolidines Time Factors Dose-Response Relationship, Drug Muscle, Smooth, Vascular Cell Proliferation rho-Associated Kinases Cell Movement Humans Thiourea rhoA GTP-Binding Protein Receptors, G-Protein-Coupled Hydrazones
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