AIMC Topic: Actin Cytoskeleton

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Distinct actin microfilament localization during early cell plate formation through deep learning-based image restoration.

Plant cell reports May 8, 2025
Using deep learning-based image restoration, we achieved high-resolution 4D imaging with minimal photodamage, revealing distinct localization and suggesting Lifeact-RFP-labeled actin microfilaments play a role in initiating cell plate formation. Phra...
Actins Plants, Genetically Modified Actin Cytoskeleton Nicotiana Deep Learning Image Processing, Computer-Assisted
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Spatiotemporal feature learning for actin dynamics.

PloS one Mar 5, 2025
The social amoeba Dictyostelium discoideum is a standard model system for studying cell motility and formation of biological patterns. D. discoideum cells form protrusions and migrate via cytoskeletal reorganization driven by coordinated waves of act...
Machine Learning Cell Movement Actins Actin Cytoskeleton Cellular Microenvironment Dictyostelium
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A deep learning framework for quantitative analysis of actin microridges.

NPJ systems biology and applications Jun 2, 2023
Microridges are evolutionarily conserved actin-rich protrusions present on the apical surface of squamous epithelial cells. In zebrafish epidermal cells, microridges form self-evolving patterns due to the underlying actomyosin network dynamics. Howev...
Zebrafish Actins Actin Cytoskeleton Actomyosin Animals Deep Learning
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Three-Dimensional Visualization of the Podocyte Actin Network Using Integrated Membrane Extraction, Electron Microscopy, and Machine Learning.

Journal of the American Society of Nephrology : JASN Nov 10, 2021
BACKGROUND: Actin stress fibers are abundant in cultured cells, but little is known about them . In podocytes, much evidence suggests that mechanobiologic mechanisms underlie podocyte shape and adhesion in health and in injury, with structural change...
Machine Learning Animals Models, Animal Imaging, Three-Dimensional Microscopy, Electron Mice Actin Cytoskeleton Mice, Inbred C57BL Podocytes
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Machine-Learning-Based Approach to Decode the Influence of Nanomaterial Properties on Their Interaction with Cells.

ACS applied materials & interfaces Dec 29, 2020
In an nanotoxicity system, cell-nanoparticle (NP) interaction leads to the surface adsorption, uptake, and changes into nuclei/cell phenotype and chemistry, as an indicator of oxidative stress, genotoxicity, and carcinogenicity. Different types of n...
Dogs Madin Darby Canine Kidney Cells Tight Junctions Dendrimers Cell Nucleus Actin Cytoskeleton Cell Nucleus Shape Epithelial Cells Zonula Occludens-1 Protein Gold Metal Nanoparticles Animals Cell Proliferation Carbon Machine Learning
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Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.

Archives of toxicology Jun 12, 2020
Accurate prediction of drug- and chemical-induced hepatotoxicity remains to be a problem for pharmaceutical companies as well as other industries and regulators. The goal of the current study was to develop an in vitro/in silico method for the rapid ...
Humans Machine Learning Phenotype Risk Assessment High-Throughput Screening Assays Microscopy, Fluorescence Toxicity Tests Cellular Senescence Transcription Factor RelA Cell Death Chemical and Drug Induced Liver Injury Primary Cell Culture Hepatocytes Image Processing, Computer-Assisted Actin Cytoskeleton Hep G2 Cells Proto-Oncogene Mas Dose-Response Relationship, Drug DNA Damage
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Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging.

Nature communications Apr 27, 2018
Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on the ensemble average of actin regulator dynamics. Here, we establish a computational framework called ...
Microfilament Proteins Potoroidae Pseudopodia Vasodilator-Stimulated Phosphoprotein Cell Adhesion Molecules Actin Cytoskeleton Intravital Microscopy Actin-Related Protein 2-3 Complex Phosphoproteins Indoles Actins Humans Cell Movement Machine Learning Cluster Analysis Software Cell Line Animals Models, Biological Cell Line, Tumor
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
rho-Associated Kinases Naphthols Signal Transduction Hydrazones rhoA GTP-Binding Protein Purinones Cell Movement Endothelial Cells Humans Thiourea Saphenous Vein Muscle, Smooth, Vascular Actin Cytoskeleton Dose-Response Relationship, Drug Time Factors HEK293 Cells Thiazolidines Aminosalicylic Acids Receptors, G-Protein-Coupled Myocytes, Smooth Muscle Cell Proliferation
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Live-Cell Labeling and Artificial Intelligence Approaches for High-Resolution XYZT Imaging of Cytoskeletal Dynamics During Collective Cell Migration.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2023
Collective cell migration is crucial for a variety of pathophysiological processes including embryonic development, wound healing, carcinoma invasion, and sprouting angiogenesis. The behavior of leading and following cells during migration is highly ...
Humans Artificial Intelligence Cell Movement Diagnostic Imaging Actin Cytoskeleton Cytoskeleton
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Network Analysis of Integrin Adhesion Complexes.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2021
Cell-surface adhesion receptors mediate interactions with the extracellular matrix (ECM) to control many fundamental aspects of cell behavior, including cell migration, survival, and proliferation. Integrin adhesion receptors recruit structural and s...
Protein Binding Computational Biology Proteome Cell Movement Neural Networks, Computer Software Animals Integrins Multiprotein Complexes Extracellular Matrix Cell Adhesion Protein Interaction Mapping Actin Cytoskeleton Humans
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