Despite the success of messenger RNA (mRNA) COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that uses transformer architectures tailored for mRNA coding seq...
Biochemical and biophysical research communications
Sep 16, 2025
CircRNAs are ubiquitously expressed across diverse tissues and cells, playing a pivotal role not only in protein-mediated biological processes but also in disease prevention and therapeutics. RNA-RBP interactions are critical for deciphering gene reg...
BACKGROUND: Numerous studies have shown that circRNA can act as a miRNA sponge, competitively binding to miRNAs, thereby regulating gene expression and disease progression. Due to the high cost and time-consuming nature of traditional wet lab experim...
Circular RNA (circRNA) represents a type of RNA molecule characterized by a closed-loop structure that is distinct from linear RNA counterparts. Recent studies have revealed the emerging role of these circular transcripts in gene regulation and disea...
BACKGROUND: RNA-binding proteins (RBPs) play crucial roles in many biological processes, and computationally identifying RNA-RBP interactions provides insights into the biological mechanism of diseases associated with RBPs.
International journal of biological macromolecules
Feb 27, 2025
As our understanding of Circular RNAs (circRNAs) continues to expand, accumulating evidence has demonstrated that circRNAs can interact with microRNAs and RNA-binding proteins to modulate gene expression. More importantly, a subset of circRNAs has be...
Interdisciplinary sciences, computational life sciences
Feb 17, 2025
Increasing evidences have indicated that circular RNAs play a crucial role in the onset and progression of various diseases. However, exploring potential disease-associated circRNAs using conventional experimental techniques remains both time-intensi...
Journal of chemical information and modeling
Feb 12, 2025
In the emerging field of RNA drugs, circular RNA (circRNA) has attracted much attention as a novel multifunctional therapeutic target. Delving deeper into the intricate interactions between circRNA and disease is critical for driving drug discovery e...
International journal of molecular sciences
Feb 11, 2025
The prediction of circular RNA (circRNA)-drug associations plays a crucial role in understanding disease mechanisms and identifying potential therapeutic targets. Traditional methods often struggle to cope with the complexity of heterogeneous network...
IEEE journal of biomedical and health informatics
Feb 10, 2025
The subcellular localization of circular RNAs (circRNAs) is crucial for understanding their functional relevance and regulatory mechanisms. CircRNA subcellular localization exhibits variations across different cell lines, demonstrating the diversity ...
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