The American journal of emergency medicine
Dec 19, 2015
OBJECTIVE: C1 inhibitor (C1INH) regulates not only the complement system but also the plasma kallikrein-kinin, fibrinolytic, and coagulation systems. The biologic activities of C1INH can be divided into the regulation of vascular permeability and ant...
PURPOSE: The Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial showed increased mortality in patients resuscitated with hydroxyethyl starch 130/0.42 (HES) vs Ringer acetate. Different effects of the fluids on the endothelium may have cont...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Nov 5, 2015
Sepsis is one of the leading causes of death in the United States. Early administration of treatment has been shown to decrease sepsis-related mortality and morbidity. Existing scoring systems such as the Acute Physiology and Chronic Health Evaluatio...
Sepsis-associated acute kidney injury (SA-AKI) patients in the ICU often suffer from sepsis-associated delirium (SAD), which is linked to unfavorable outcomes. This research aimed to develop a machine learning-based model for early SAD prediction in ...
IEEE transactions on bio-medical engineering
Nov 1, 2025
While machine learning (ML) techniques have been applied to detection and prediction tasks in clinical data, most methods rely on high-resolution data, which is not routinely available in most Intensive Care Units (ICUs), and perform poorly when face...
Clinical chemistry and laboratory medicine
Sep 25, 2025
OBJECTIVES: Machine learning (ML) models, using laboratory data, support early sepsis prediction. However, analytical bias in laboratory measurements can compromise their performance and validity in real-world settings. We aimed to evaluate how analy...
The journal of applied laboratory medicine
Sep 3, 2025
BACKGROUND: Sepsis is a life-threatening condition that is one of the major causes of death worldwide. Early detection of sepsis is required for fast initialization of an appropriate therapy. Complete blood count data containing information about whi...
In critical care medicine, sepsis management represents a critical barrier to improving clinical outcomes, primarily due to the disease's profound heterogeneity and the current inability to optimally identify patient subgroups benefiting from persona...
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
The kidney is a target organ for the dysregulated host response to infection that defines sepsis, and acute kidney injury (AKI) is often an early manifestation of this response. Current sepsis criteria for adults (Sepsis-3) continue to include outmod...
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