AIMC Topic: Single-Cell Gene Expression Analysis

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Investigation of cell development and tissue structure network based on natural Language processing of scRNA-seq data.

Journal of translational medicine Mar 4, 2025
BACKGROUND: Single-cell multi-omics technologies, particularly single-cell RNA sequencing (scRNA-seq), have revolutionized our understanding of cellular heterogeneity and development by providing insights into gene expression at the single-cell level...
Cell Differentiation Organ Specificity Single-Cell Gene Expression Analysis Sequence Analysis, RNA Natural Language Processing Animals Humans Single-Cell Analysis RNA-Seq Gene Regulatory Networks
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The Role of Autophagy and Cell Communication in COPD Progression: Insights from Bioinformatics and scRNA-seq.

COPD Feb 24, 2025
Chronic obstructive pulmonary disease (COPD) is characterized by restricted airflow that leads to significant respiratory difficulties. This progressive disease often results in diminished pulmonary function and the onset of additional respiratory co...
Humans Pulmonary Disease, Chronic Obstructive Epithelial Cells Autophagy Cell Communication Smoking Disease Progression RNA-Seq Single-Cell Gene Expression Analysis Computational Biology
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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning.

Frontiers in immunology Jan 24, 2025
INTRODUCTION: Type 2 diabetes (T2D) is a complex metabolic disorder with significant global health implications. Understanding the molecular mechanisms underlying T2D is crucial for developing effective therapeutic strategies. This study employs sing...
RNA-Seq Diabetes Mellitus, Type 2 Gene Regulatory Networks Metals Single-Cell Analysis Single-Cell Gene Expression Analysis Protein Interaction Maps Ion Transport Humans Machine Learning Gene Expression Profiling
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Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis.

Journal of translational medicine Dec 20, 2024
BACKGROUND: Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions. Tryptophan metabolism has been believed as a significant factor in UC pathogenesis, with s...
Machine Learning Algorithms Single-Cell Analysis RNA-Seq Humans Single-Cell Gene Expression Analysis Colitis, Ulcerative Tryptophan
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Integration of bulk/scRNA-seq and multiple machine learning algorithms identifies PIM1 as a biomarker associated with cuproptosis and ferroptosis in abdominal aortic aneurysm.

Frontiers in immunology Dec 11, 2024
BACKGROUND: Abdominal aortic aneurysm (AAA) is a serious life-threatening vascular disease, and its ferroptosis/cuproptosis markers have not yet been characterized. This study was aiming to identify markers associated with ferroptosis/cuproptosis in ...
Gene Expression Profiling RNA-Seq Single-Cell Gene Expression Analysis Mice Biomarkers Humans Animals Male Machine Learning Proto-Oncogene Proteins c-pim-1 Algorithms Computational Biology Disease Models, Animal Ferroptosis Aortic Aneurysm, Abdominal
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Essential blood molecular signature for progression of sepsis-induced acute lung injury: Integrated bioinformatic, single-cell RNA Seq and machine learning analysis.

International journal of biological macromolecules Oct 31, 2024
In this study, we aimed to identify an essential blood molecular signature for chacterizing the progression of sepsis-induced acute lung injury using integrated bioinformatic and machine learning analysis. The results showed that a total of 88 functi...
Machine Learning Biomarkers Animals Male Humans Mice Computational Biology Acute Lung Injury Sepsis Single-Cell Analysis RNA-Seq Single-Cell Gene Expression Analysis Disease Progression Gene Expression Profiling Transcriptome
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Impact of Mitophagy-Related Genes on the Diagnosis and Development of Esophageal Squamous Cell Carcinoma via Single-Cell RNA-seq Analysis and Machine Learning Algorithms.

Journal of microbiology and biotechnology Sep 23, 2024
As a treatment for esophageal squamous cell carcinoma (ESCC), which is common and fatal, mitophagy is a conserved cellular mechanism that selectively removes damaged mitochondria and is crucial for cellular homeostasis. While tumor development and re...
Humans Machine Learning Algorithms Prognosis Biomarkers, Tumor Transcriptome Esophageal Neoplasms Mitochondria Esophageal Squamous Cell Carcinoma Apoptosis Regulatory Proteins Mitochondrial Proteins Mitophagy Single-Cell Gene Expression Analysis Gene Expression Regulation, Neoplastic Cell Proliferation Cell Movement Cell Line, Tumor Single-Cell Analysis RNA-Seq
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Integrating large-scale single-cell RNA sequencing in central nervous system disease using self-supervised contrastive learning.

Communications biology Sep 10, 2024
The central nervous system (CNS) comprises a diverse range of brain cell types with distinct functions and gene expression profiles. Although single-cell RNA sequencing (scRNA-seq) provides new insights into the brain cell atlases, integrating large-...
Humans Animals Atlases as Topic Neurodegenerative Diseases Deep Learning Supervised Machine Learning Single-Cell Gene Expression Analysis Datasets as Topic Cluster Analysis Central Nervous System
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Bridging gaps: a neural network approach for cross-species scRNA-seq analysis in COVID-19.

EBioMedicine Sep 4, 2024
Single-Cell Gene Expression Analysis Sequence Analysis, RNA Humans Neural Networks, Computer COVID-19 SARS-CoV-2 Animals Single-Cell Analysis
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Machine-learning and scRNA-Seq-based diagnostic and prognostic models illustrating survival and therapy response of lung adenocarcinoma.

Genes and immunity Jul 29, 2024
Lung cancer is a major cause accounting for cancer-related mortalities, with lung adenocarcinoma (LUAD) being the most prevalent subtype. Given the high clinical and cellular heterogeneities of LUAD, accurate diagnosis and prognosis are crucial to av...
Adenocarcinoma of Lung Male RNA-Seq Single-Cell Gene Expression Analysis Lung Neoplasms Female Tumor Microenvironment Biomarkers, Tumor Humans Machine Learning Prognosis
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