AIMC Topic: Spike Glycoprotein, Coronavirus

Clear Filters Showing 31 to 40 of 51 articles

Predicting the animal hosts of coronaviruses from compositional biases of spike protein and whole genome sequences through machine learning.

PLoS pathogens Apr 20, 2021
The COVID-19 pandemic has demonstrated the serious potential for novel zoonotic coronaviruses to emerge and cause major outbreaks. The immediate animal origin of the causative virus, SARS-CoV-2, remains unknown, a notoriously challenging task for eme...
Biological Evolution Coronaviridae Coronaviridae Infections Phylogeny Spike Glycoprotein, Coronavirus Genome, Viral Machine Learning Animals
View on PubMed DOI

DeepAlign, a 3D alignment method based on regionalized deep learning for Cryo-EM.

Journal of structural biology Mar 4, 2021
Cryo Electron Microscopy (Cryo-EM) is currently one of the main tools to reveal the structural information of biological specimens at high resolution. Despite the great development of the techniques involved to solve the biological structures with Cr...
Workflow Deep Learning Signal-To-Noise Ratio Neural Networks, Computer Imaging, Three-Dimensional Cryoelectron Microscopy Spike Glycoprotein, Coronavirus Ribosome Subunits Plasmodium falciparum
View on PubMed DOI

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study.

Scientific reports Feb 5, 2021
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical the...
COVID-19 Vaccines Spike Glycoprotein, Coronavirus Computational Biology Models, Molecular Epitopes, T-Lymphocyte Molecular Docking Simulation Drug Design Deep Learning Solubility Immunogenicity, Vaccine T-Lymphocytes, Helper-Inducer Protein Conformation Epitopes, B-Lymphocyte Mutation RNA, Viral Molecular Dynamics Simulation Allergens Humans COVID-19 SARS-CoV-2 Vaccines, Subunit T-Lymphocytes, Cytotoxic Codon Usage
View on PubMed DOI

Predicting Potential SARS-COV-2 Drugs-In Depth Drug Database Screening Using Deep Neural Network Framework SSnet, Classical Virtual Screening and Docking.

International journal of molecular sciences Feb 4, 2021
Severe Acute Respiratory Syndrome Corona Virus 2 has altered life on a global scale. A concerted effort from research labs around the world resulted in the identification of potential pharmaceutical treatments for CoVID-19 using existing drugs, as we...
Spike Glycoprotein, Coronavirus Drug Repositioning Drug Evaluation, Preclinical COVID-19 Drug Treatment Angiotensin-Converting Enzyme 2 Humans Databases, Pharmaceutical SARS-CoV-2 Molecular Docking Simulation Neural Networks, Computer Drug Discovery Machine Learning Antiviral Agents COVID-19 Algorithms
View on PubMed DOI

Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs.

Scientific reports Dec 23, 2020
The global population is at present suffering from a pandemic of Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The goal of this study was to use artificial intellige...
Proteomics Proteome Mutation HLA Antigens Amino Acid Sequence Haplotypes Humans Immunogenicity, Vaccine Drug Evaluation, Preclinical Machine Learning Alleles SARS-CoV-2 Epitopes, T-Lymphocyte COVID-19 Vaccines Software Spike Glycoprotein, Coronavirus Pandemics COVID-19 Algorithms
View on PubMed DOI

Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.

Chemical biology & drug design Dec 22, 2020
The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. To evaluate molec...
Cell Survival Molecular Docking Simulation Drug Repositioning Antiviral Agents Humans Structure-Activity Relationship Deoxyadenosines Spike Glycoprotein, Coronavirus COVID-19 Drug Treatment Machine Learning Binding Sites Viral Matrix Proteins Cell Line COVID-19 Protease Inhibitors SARS-CoV-2
View on PubMed DOI

Identification and validation of 174 COVID-19 vaccine candidate epitopes reveals low performance of common epitope prediction tools.

Scientific reports Nov 24, 2020
The outbreak of SARS-CoV-2 (2019-nCoV) virus has highlighted the need for fast and efficacious vaccine development. Stimulation of a proper immune response that leads to protection is highly dependent on presentation of epitopes to circulating T-cell...
SARS-CoV-2 Epitopes, T-Lymphocyte Peptides COVID-19 Vaccines Histocompatibility Antigens Class I Humans Histocompatibility Antigens Class II Spike Glycoprotein, Coronavirus Machine Learning Base Sequence Computational Biology COVID-19 HLA Antigens Alleles
View on PubMed DOI

Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone.

Biochemical and biophysical research communications Sep 18, 2020
Coronaviruses infect many animals, including humans, due to interspecies transmission. Three of the known human coronaviruses: MERS, SARS-CoV-1, and SARS-CoV-2, the pathogen for the COVID-19 pandemic, cause severe disease. Improved methods to predict...
Coronavirus Humans Machine Learning Animals Spike Glycoprotein, Coronavirus Computational Biology Host Specificity
View on PubMed DOI

Screening of Therapeutic Agents for COVID-19 Using Machine Learning and Ensemble Docking Studies.

The journal of physical chemistry letters Aug 14, 2020
The current pandemic demands a search for therapeutic agents against the novel coronavirus SARS-CoV-2. Here, we present an efficient computational strategy that combines machine learning (ML)-based models and high-fidelity ensemble docking studies to...
Hydrogen Bonding Antiviral Agents Humans Betacoronavirus Spike Glycoprotein, Coronavirus Machine Learning Drug Evaluation, Preclinical SARS-CoV-2 Protein Conformation Molecular Docking Simulation
View on PubMed DOI

Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome (PCVS) individuals.

Human vaccines & immunotherapeutics Dec 1, 2025
Despite over 13 billion SARS-CoV-2 vaccine doses administered globally, persistent post-vaccination symptoms, termed post-COVID-19 vaccine syndrome (PCVS), resemble post-acute sequelae of COVID-19 (PASC). Symptoms like cardiac, vascular, and neurolog...
COVID-19 Cytokines Female SARS-CoV-2 Humans COVID-19 Vaccines Spike Glycoprotein, Coronavirus Aged Monocytes Adult GPI-Linked Proteins Male Receptors, IgG Middle Aged
View on PubMed DOI
Popular Topics
Recent Journals