N- methyladenosine (mA) is a vital post-transcriptional modification, which adds another layer of epigenetic regulation at RNA level. It chemically modifies mRNA that effects protein expression. RNA sequence contains many genetic code motifs (GAC). A...
Neural networks : the official journal of the International Neural Network Society
Jul 19, 2018
The solution of an LS-SVM has suffered from the problem of non-sparseness. The paper proposed to apply the KMP algorithm, with the number of support vectors as the regularization parameter, to tackle the non-sparseness problem of LS-SVMs. The idea of...
IEEE journal of biomedical and health informatics
Jul 18, 2018
Using a single imaging modality to diagnose Alzheimer's disease (AD) or mild cognitive impairment (MCI) is a challenging task. FluoroDeoxyGlucose Positron Emission Tomography (FDG-PET) is an important and effective modality used for that purpose. In ...
Recent neuroimaging studies identified posterior regions in the temporal and parietal lobes as neuro-functional correlates of subitizing and global Gestalt perception. Beyond notable overlap on a neuronal level both mechanisms are remarkably similar ...
OBJECTIVE: Application of machine learning techniques for automatic and reliable classification of clinical documents have shown promising results. However, machine learning models require abundant training data specific to each target hospital and m...
Attention Deficit Hyperactive Disorder (ADHD) is one of the most common diseases in school aged children. In this paper, we consider using fMRI data with classification techniques to aid the diagnosis of ADHD and propose a bi-objective ADHD classific...
The mammalian visual system consists of several anatomically distinct areas, layers, and cell types. To understand the role of these subpopulations in visual information processing, we analyzed neural signals recorded from excitatory neurons from var...
IEEE journal of biomedical and health informatics
Jul 16, 2018
Development of new medications is a lengthy and costly process, and drug repositioning might help to shorten the development cycle. We present a machine learning (ML) workflow to drug discovery or repositioning by predicting indication for a particul...
In silico models are presented for modeling and predicting thyroid hormone receptor (TR) agonists and antagonists. A data set consisting of 258 compounds is used in the present work. The C4.5, random forest (RF) and support vector machine (SVM) stati...
International journal of molecular sciences
Jul 16, 2018
Amyloid is an insoluble fibrous protein and its mis-aggregation can lead to some diseases, such as Alzheimer's disease and Creutzfeldt⁻Jakob's disease. Therefore, the identification of amyloid is essential for the discovery and understanding of disea...
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