BACKGROUND: Data on neoadjuvant treatment with trastuzumab biosimilars, particularly CT-P6, in combination with pertuzumab, are limited. This study evaluates the efficacy, tolerability, and immunogenicity of CT-P6 plus pertuzumab and chemotherapy, in...
Medical oncology (Northwood, London, England)
Jan 13, 2026
Recent advances in Medical Oncology highlight the integration of bulk and single-cell transcriptomics to reveal glycolytic heterogeneity in colorectal cancer. Translating these discoveries into reliable clinical tools requires rigorous methods, trans...
The development of neoantigen-based cancer vaccines has emerged as a groundbreaking approach in the field of personalized oncology. Neoantigens, originating from tumor-specific somatic mutations, possess considerable immunogenic potential and are abs...
The ability to detect nucleic acids at ever-lower detection limits is crucial in molecular science, enabling disease management to shift from reactive response to proactive prediction and personalized medicine. This review synthesizes the technologic...
The global burden of cancer is rising, with treatment failures often due to the metastatic nature of late-stage malignancies. Circulating tumour cells (CTCs) are metastatic precursors shed from primary tumours, which survive in circulation, extravasa...
Journal of controlled release : official journal of the Controlled Release Society
Aug 25, 2025
The clinical translation of DDS is still one of the most challenging issues for the further development of therapeutic breakthroughs, especially for cancer and complex diseases. This review provides a critical overview of the factors that influence t...
Cancer remains one of the leading causes of death worldwide, with therapy resistance and tumor recurrence driven by a subpopulation of cells known as cancer stem cells (CSCs). CSCs possess a remarkable ability to evade apoptosis, adapt to harsh micro...
Multiplexed imaging techniques require identifying different cell types in the tissue. To utilize their potential for cellular and molecular analysis, high throughput and accurate analytical approaches are needed in parsing vast amounts of data, part...
The global burden of cardiovascular diseases continues to rise, making their prevention, diagnosis and treatment increasingly critical. With advancements and breakthroughs in omics technologies such as high-throughput sequencing, multi-omics approach...
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Mar 14, 2025
Basic and translational research (B&TR) in liver transplantation (LT) underwent considerable changes and shifts over the past decade. To capture the current landscape and future potential of B&TR in LT, we conducted an online survey within the Inte...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.