BACKGROUND: The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, usi...
INTRODUCTION: The substantial case detection gap in the field of child tuberculosis (TB) disease is largely driven by inadequate diagnostic tools and approaches. Chest radiographs (CXRs) remain a key component in the evaluation of children and young ...
One of the most common infectious disease-related causes of death globally, particularly in low- and middle-income nations, persists: tuberculosis. At a manifestation of globalization, causes of death keep growing. As it happens, we have developed a ...
The role of chromatin regulators (CRs) in mediating epigenetic changes during tuberculosis (TB) infection remains poorly understood. This study aimed to determine the efficacy of CRs in diagnosing TB and characterizing its heterogeneity. GSE83456 dat...
Air pollution is the fifth and sixth leading risk factor for global mortality and reduced life expectancy. Studies have established a link between atmospheric pollution and the incidence, hospitalization, and mortality rates of pulmonary tuberculosis...
BACKGROUND: HIV/TB co-infection presents substantial public-health challenges, showing greater treatment-failure and mortality rates than tuberculosis alone. Recent advances in machine learning (ML) provide a robust means of identifying high-risk pat...
Journal of computer-aided molecular design
Nov 4, 2025
Mycobacterium tuberculosis (Mtb) continues to be one of the major contributors to the global burden of infectious diseases. Many drugs used in the current treatment regime have fallen prey to the puzzling phenomenon of antimicrobial resistance. Despi...
The Kashgar region, located in Northwest China, has a significantly higher incidence of tuberculosis (TB) compared to the national average. Local governments conduct annual TB screening using medical imaging. However, due to a shortage of radiologist...
Africa's vast genetic diversity poses challenges for optimising drug treatments in the continent, which is exacerbated by the fact that drug discovery and development efforts have historically been performed outside Africa. This has led to suboptimal...
OBJECTIVES: Rapid discrimination of infections caused by (MTB) and non-tuberculous mycobacteria (NTM) is crucial in clinical settings. Despite overlapping clinical and radiological features, the two require markedly different therapeutic approaches ...
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