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Unsupervised Machine Learning

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Prediction of Potential miRNA-Disease Associations Through a Novel Unsupervised Deep Learning Framework with Variational Autoencoder.

Cells
The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational aut...

Learning unsupervised feature representations for single cell microscopy images with paired cell inpainting.

PLoS computational biology
Cellular microscopy images contain rich insights about biology. To extract this information, researchers use features, or measurements of the patterns of interest in the images. Here, we introduce a convolutional neural network (CNN) to automatically...

PET image denoising using unsupervised deep learning.

European journal of nuclear medicine and molecular imaging
PURPOSE: Image quality of positron emission tomography (PET) is limited by various physical degradation factors. Our study aims to perform PET image denoising by utilizing prior information from the same patient. The proposed method is based on unsup...

Adversarial learning for mono- or multi-modal registration.

Medical image analysis
This paper introduces an unsupervised adversarial similarity network for image registration. Unlike existing deep learning registration methods, our approach can train a deformable registration network without the need of ground-truth deformations an...

Adaptive Resonance Theory in the time scales calculus.

Neural networks : the official journal of the International Neural Network Society
Engineering applications of algorithms based on Adaptive Resonance Theory have proven to be fast, reliable, and scalable solutions to modern industrial machine learning problems. A key emerging area of research is in the combination of different kind...

Quantifying the effects of data augmentation and stain color normalization in convolutional neural networks for computational pathology.

Medical image analysis
Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance. Due to this color shift between laboratories, convolutional neural networks (CNNs) trained with...

Unsupervised method for normalization of hematoxylin-eosin stain in histological images.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Histological images stained with hematoxylin-eosin are widely used by pathologists for cancer diagnosis. However, these images can have color variations that highly influence the histological image processing techniques. To deal with this potential l...

Physiological indices of challenge and threat: A data-driven investigation of autonomic nervous system reactivity during an active coping stressor task.

Psychophysiology
We utilized a data-driven, unsupervised machine learning approach to examine patterns of peripheral physiological responses during a motivated performance context across two large, independent data sets, each with multiple peripheral physiological me...

HetEnc: a deep learning predictive model for multi-type biological dataset.

BMC genomics
BACKGROUND: Researchers today are generating unprecedented amounts of biological data. One trend in current biological research is integrated analysis with multi-platform data. Effective integration of multi-platform data into the solution of a singl...