AIMC Topic: Virus Replication
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Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.
PloS one
Jul 26, 2018
Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel drug targets. We have previously screened a collection of highly characterized kinase inhibitors (Khan...
Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid.
Journal of the Chinese Medical Association : JCMA
Dec 26, 2017
BACKGROUND: The pandemic influenza A (H1N1) virus has spread worldwide and infected a large proportion of the human population. Discovery of new and effective drugs for the treatment of influenza is a crucial issue for the global medical community. A...
Paraconsistents artificial neural networks applied to the study of mutational patterns of the F subtype of the viral strains of HIV-1 to antiretroviral therapy.
Anais da Academia Brasileira de Ciencias
Mar 4, 2016
The high variability of HIV-1 as well as the lack of efficient repair mechanisms during the stages of viral replication, contribute to the rapid emergence of HIV-1 strains resistant to antiretroviral drugs. The selective pressure exerted by the drug ...
Use of uniform designs in combination with neural networks for viral infection process development.
Biotechnology progress
Jan 27, 2015
This work aimed to compare the predictive capacity of empirical models, based on the uniform design utilization combined to artificial neural networks with respect to classical factorial designs in bioprocess, using as example the rabies virus replic...
The Spontaneous Control of HIV Replication is Characterized by Decreased Pathological Changes in the Gut-associated Lymphoid Tissue.
Current HIV research
Jan 1, 2018
BACKGROUND: HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, severa...
High Mobility Group Box 1 Protein Enhances HIV Replication in Newly Infected Primary T Cells.
Clinical laboratory
Dec 1, 2016
BACKGROUND: High-mobility group box 1 (HMGB1), a DNA-binding protein, has recently been shown to have effects on HIV replication, but the effects are dependent on the cell type and the timing of infection. Using human primary T cells, this study aime...
Interferon-α and inosine pranobex-mediated inhibition of reploication of human RNA viruses in vitro.
Medycyna doswiadczalna i mikrobiologia
Jan 1, 2016
INTRODUCTION: Interferon- a (IFN-a), produced by immune cells, exhibits pleiotropic anti- viral activity. Inosine pranobex (PI), a synthetic derivative of a purine, shows direct anti- viral activity, and also acts indirectly, by activation of immune ...
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