Allergy

Cardiovascular Toxicity Across the Cancer Immunotherapy Spectrum: Mechanisms and Management in Immune Checkpoint Inhibitor (ICI) and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy.

PURPOSE OF REVIEW: This review evaluates the evolving landscape of cardiovascular toxicities associa...

Deep learning assessment of visualization in rotator cuff repair: a secondary analysis of a randomized controlled trial comparing epinephrine irrigation and intravenous tranexamic acid.

BACKGROUND: This study aimed to compare intraoperative visualization between diluted epinephrine (EP...

Geriatric respiratory medicine 2026: from artificial intelligence to personalised management of the multimorbid patient.

The profound demographic shift toward an ageing population has decisively moved the burden of chroni...

CYP1B1 is a potential target of kaempferol in renal fibrosis: a multi‑omics and single‑cell transcriptomics study.

BACKGROUND: Renal fibrosis (RF) is a progressive and irreversible pathological process for which eff...

Decoding autoimmune diseases through the adaptive immune receptor repertoires.

The adaptive immune receptor repertoire (AIRR), composed of T-cell receptors (TCRs) and B-cell recep...

Recovering CDR3 sequences from RNA-seq data: a critical assessment of computational and experimental strategies.

The adaptive immune response depends on T cell receptor (TCR) diversity to counter cancers, autoimmu...

P-WIN deployment: real-time personalized machine learning to predict critical deterioration in a pediatric intensive care unit.

OBJECTIVES: Early recognition of critical deterioration events (CDEs) in pediatric intensive care un...

Relationship extraction for adverse drug events in clinical notes using large language models: a retrospective cross-sectional study.

BACKGROUND: Adverse drug events (ADEs) are a critical indicator of patient safety but are often docu...

The potential of personalized cancer spheroids in precision therapy.

The clinical implementation of precision oncology remains challenged by intratumoral heterogeneity, ...

Oral squamous cell carcinoma: A Modern Review of Pathogenesis and Treatment.

Oral cancer (OC), predominantly oral squamous cell carcinoma (OSCC), is a serious global health burd...

From HPV infection to cervical precancer: Molecular mechanisms, immune microenvironment and emerging technologies.

Cervical cancer remains a leading cause of cancer-related mortality among women globally, with persi...

Using informatics to understand pediatric allergic diseases.

PURPOSE OF REVIEW: Recent advances in the power, utility, and accessibility of artificial intelligen...

Performance Evaluation of an Artificial Intelligence-Assisted Digital Morphology System for Bone Marrow Aspirate Examination.

INTRODUCTION: Morphological examination of bone marrow aspirates (BMA) remains essential for the dia...

Comprehensive Multicenter Evaluation of an AI-Based Deep Learning System for Automated Blood Cell Classification and Morphologic Analysis.

BACKGROUND AND OBJECTIVES: Deep learning-based systems have shown promise in automating white blood ...

Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.

Metabolic reprogramming is a core feature of tumor cells in adapting to microenvironmental stress an...

Zeolitic imidazolate frameworks for lung cancer diagnosis and therapy: design principles and biomedical applications.

Lung cancer remains one of the most prevalent and lethal malignancies worldwide, with its clinical m...

Regarding "Machine Learning Model Development and Validation in Individuals With Suggestive Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs".

SmartVax-Bp: An Immunoinformatic guided Multi-Epitope Vaccine Blueprint Against Burkholderia pseudomallei.

Burkholderia pseudomallei (B. pseudomallei) is the causative agent of melioidosis, a potentially ser...

Comprehensive analysis and external validation of a glycolysis-related gene signature as a prognostic index for skin cutaneous melanoma.

Skin cutaneous melanoma (SKCM) is the third most common cause of cancer-related deaths globally. Tod...

Successful predictive modeling of pollen fitness phenotypes is enabled by measures of expression specificity.

The ability to predict phenotypes from genotypes in multicellular organisms remains limited despite ...

Proteomics for cultivated meat: Current insights and research frontiers.

Cultivated meat, produced through cellular agriculture, is emerging as an alternative to conventiona...