Infectious Disease

COVID-19

Latest AI and machine learning research in covid-19 for healthcare professionals.

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An Accurate Glucose Detection Platform Using Colorimetry and Supervised Learning Algorithms.

Maintaining optimal health and preventing diabetes-related complications require accurate and timely monitoring of blood glucose levels. In this context, the present study develops an affordable, reliable, and precise Point-of-Care (POC) diagnostic platform for glucose detection by integrating microfluidic and colorimetric principles. The system uses a custom-fabricated microfluidic chip that enab...

Mar 9 2026 41802365

NAStructuralDB : structural database to facilitate computational studies of molecular modeling and recognition of proteins with special focus on antibody-antigen interactions.

Studying the interactions between antibodies and antigens is fundamental to the development of novel therapeutic biologics. Predictions of such interactions start with data collection. Though there exist reliable resources to identify antibody structures in the Protein Data Bank (PDB), such data still requires substantial processing to be usable in predictive tasks. Redundancy in sequences needs t...

Mar 8 2026 41797001
IMMT downregulation promotes osteoarthritis development by inducing mitochondrial dysfunction.

OBJECTIVE: This study aimed to identify key mitochondria-related genes involved in the pathogenesis of osteoarthritis (OA). METHODS: Publicly availabl...

Mar 8 2026 41794759
6PPD-quinone promotes ovarian cancer progression: Insights from network toxicology, machine learning, and in vitro validation.

6PPD-quinone (6PPD-Q), a toxic tire-derived antioxidant transformation product, is a pervasive environmental contaminant linked to reproductive toxici...

Mar 6 2026 41796632
Pharmacokinetic modeling to optimize development and therapeutic potential of mAb-based therapies.

Monoclonal antibody (mAb)-based therapies have revolutionized modern medicine, offering highly specific and effective treatments for a wide range of d...

Mar 6 2026 41796750
Overcoming gastrointestinal mucosal barriers: Mechanistic innovations and technical advances in mucosal targeting strategies for animal oral vaccines.

Infectious diseases caused by pathogenic microorganisms (such as Escherichia coli, Avian influenza virus (AIV), Rotavirus, etc.) that primarily invade...

Mar 6 2026 41819733
Radiomics-based ultrasOund Model for differentiating Uterine Sarcomas from leiomyomas (ROMUS): a retrospective pilot Multicenter Italian Trials in Ovarian Cancer (MITO) study.

OBJECTIVE: To develop machine-learning models that incorporate clinical information and radiomics features extracted from ultrasound images to disting...

Mar 6 2026 41791853
From tests to truth: A misclassification-aware machine learning framework for estimating brucellosis seroprevalence in wild canids.

Brucellosis is an important zoonotic disease affecting humans, livestock, and wildlife, yet prevalence estimates in wild species are often underestima...

Mar 6 2026 41790615
Predictive divergence in machine learning models for clinical mortality risk: A multicohort study of covid-19 patients.

BACKGROUND: Machine learning (ML) algorithms are increasingly used in healthcare to support clinical decision-making. While models with similar overal...

Mar 6 2026 41790775
Cross-Cultural Differences in Public Discourse on COVID-19 Vaccination in the United States and South Korea: Cross-Sectional Analysis Using Natural Language Processing.

BACKGROUND: The COVID-19 vaccine was introduced as a crucial tool to combat the pandemic. However, concerns about its effectiveness, side effects, and...

Mar 5 2026 41785455
From Antigen to Atlas: A Multi-omics, Single-Cell Pipeline for Discovering Safe and Effective CAR Targets in Ovarian Cancer.

Chimeric antigen receptor (CAR) T-cell therapy has achieved remarkable success in hematologic malignancies but continues to face significant barriers ...

Mar 5 2026 41794160
Functional Data Strengthen Clinical Validation of PhenoScore Phenotype-Guided AI for ANKRD11 Missense Variants.

KBG syndrome (KBGS, OMIM #148050) is a rare genetic disorder caused by heterozygous truncating or missense variants in the ANKRD11 gene or a deletion ...

Mar 5 2026 41786677
Development and validation of case-finding algorithms for identifying patients with systemic lupus erythematosus in an administrative claim database from tertiary care centers in Japan.

OBJECTIVE: To develop and validate algorithms for identifying patients with systemic lupus erythematosus (SLE) in Japanese administrative claims datab...

Mar 5 2026 41071117
Biosensor-based diagnosis for infectious diseases: Nano-enabled revolution.

Infectious diseases (IDs) pose a significant global health threat, exacerbated by the rise of multidrug-resistant (MDR) and antimicrobial-resistant (A...

Mar 4 2026 41791433
CAR T-cells in hematologic malignancies: Advances, challenges, and future directions.

Chimeric antigen receptor (CAR) T-cell therapy has transformed the management of hematologic malignancies, achieving high remission rates in relapsed ...

Mar 4 2026 41940327
Fully automated, deep learning, cardiac CT-based multimodal network for cardiovascular risk stratification in high-risk perioperative patients.

AIMS: Major adverse cardiac events (MACE) significantly impact perioperative morbidity and mortality. We aimed to develop a fully automated multimodal...

Mar 4 2026 41836588
Genotype and Age at Onset Drive Vermis Atrophy in CACNA1A- and GAA-FGF14-related Ataxias.

UNLABELLED: CACNA1A- and GAA-FGF14-related channelopathies are among the most frequent genetic etiologies of cerebellar ataxia. They display overlappi...

Mar 4 2026 41775907
Peak Oxygen Uptake Prediction From Resting and Submaximal Variables of Cardiopulmonary Exercise Testing.

BACKGROUND: Cardiorespiratory fitness, as measured by peak oxygen uptake during cardiopulmonary exercise testing, is a prognostic indicator. We aim to...

Mar 4 2026 41778608
3D region-growing nnU-Net improves pulmonary embolism detection on CTPA: a dual-cohort validation study.

OBJECTIVES: We compared three customized nnU-Net models (A: baseline two-dimensional (2D); B: 2D + region-growing; C: three-dimensional (3D) + region-...

Mar 4 2026 41779309
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