Genetics

Latest AI and machine learning research in genetics for healthcare professionals.

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Development and interpretation of a pathomics-based model for the prediction of immune therapy response in colorectal cancer.

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-r...

Transcriptomic signatures of rare variant impacts across sex and the X chromosome.

The human X chromosome contains hundreds of genes and has well-established impacts on sex difference...

DNA forensics at forty: the way forward.

Forensic DNA analysis has transformed criminal investigations since its inception in 1985. Over four...

Anoikis in hepatocellular carcinoma: genetic alterations and immune microenvironment insights from single-cell and computational analysis.

BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by high heterogeneity, and its molecular...

Prediction of Lymph Node Metastasis in Non-Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data.

PURPOSE: Lymph node metastasis (LNM) significantly affects prognosis and treatment strategies in non...

Integrative strategies in drug discovery: Harnessing genomics, deep learning, and computer-aided drug design.

The development of novel drugs increasingly relies on advanced omics technologies, including genomic...

A review of enhanced biosignature immunotherapy tools for predicting lung cancer immune phenotypes using deep learning.

Cancer has increasingly been recognized as a genetic disease, influenced by lifestyle changes, dieta...

Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia.

BCR::ABL1-targeting tyrosine kinase inhibitors (TKIs) dominate the treatment of chronic myeloid leuk...

Development of an immune scoring system based on exosome-related gene expression for prognosis and treatment response prediction in breast cancer.

Breast cancer (BC) is a heterogeneous disease with diverse subtypes that influence prognosis and tre...

Revolutionizing breast cancer immunotherapy by integrating AI and nanotechnology approaches: review of current applications and future directions.

Breast cancer (BC) is still the most diagnosed cancer for females with an increased focus on immunot...

Multi-Omics-Based Characterization of DNA Methylation Episignatures for Papillary Thyroid Cancer in a Chinese Population.

Thyroid cancer is the most common endocrine malignancy, with papillary thyroid cancer (PTC) account...

Cryo-ablation management of atrial fibrillation in Fabry disease without agalsidase alpha: a case report.

Fabry disease (FD) is a rare genetic disorder caused by mutations in the gene, affecting multiple o...

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening.

INTRODUCTION: Data-driven omics approaches have rapidly advanced our understanding of the molecular ...

Integrating Radiogenomics and Machine Learning in Musculoskeletal Oncology Care.

Musculoskeletal tumors present a diagnostic challenge due to their rarity, histological diversity, a...

Advances in the Directed Evolution of Computer-aided Enzymes.

Experimental-driven directed evolution has achieved remarkable success in enzyme engineering. Howeve...

Genome-wide Association Studies of the Pathogenic Sphingosine-1-Phosphate Gene in Ulcerative Colitis.

BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that can lead to maligna...

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