Liver Transplantation

[Sarcoidosis-associated uveitis: Current status and future prospects].

Sarcoidosis-related uveitis is the most common manifestation of ocular sarcoidosis. It can occur at any age but preferentially affects adults aged 30 to 60 years, with a female predominance, especially in forms with late onset. Suggestive semiological features are: granulomatous anterior uveitis defined by thick retro-descemetal precipitates (so-called "mutton-fat" keratic precipitates) or iris no...

VN1K is a pangenome-informed multi-omics and phenomics resource for the Vietnamese population.

The population of Vietnam remains underrepresented in global genomic databases. Here, we present VN1K, a resource of multi-omics and phenotypic information for 1011 unrelated Vietnamese individuals. We present high-depth short-read whole-genome sequencing data for all samples along with various -omics datasets. Using a high-sensitivity variant detection pipeline, which includes a pangenome graph r...

Keratin gene expression signature predicts prognosis and immunotherapy efficacy in lung adenocarcinoma.

Keratins (KRTs) are intermediate filament proteins expressed in epithelial cells and serve as diagnostic cancer biomarkers. They serve pivotal roles i...

Recent Advances in Immunotherapy for Breast Cancer: An Updated Review.

Immunotherapy has revolutionized the treatment landscape of breast cancer, particularly for triple-negative breast cancer (TNBC), yet primary and acqu...

Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy.

While gasdermin (GSDM)-mediated pyroptosis is a potent immune effector, its antiviral potential remains largely untapped. Here, we introduce viral pro...

DeepHeptox: An Interpretable Deep Learning Model for Multi-Endpoint Hepatotoxicity Prediction of Chemical Compounds.

Hepatotoxicity represents a major adverse outcome of chemical exposure, as the liver plays a central role in xenobiotic metabolism and detoxification....

A combi-elasto ultrasound based deep learning model on liver fibrosis staging for suspected MASLD/MASH patients.

OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) weakened the ...

Hypoxia tumor-associated macrophages facilitate hepatocellular carcinoma metastasis via uPA-uPAR pathway.

BACKGROUND: Hepatocellular carcinoma (HCC) arises within a hypoxic and immunosuppressive tumor microenvironment (TME), where tumor-associated macropha...

Precision Medicine for Anticoagulation Strategies in the Cath Lab: Part 2.

PURPOSE OF REVIEW: Intraprocedural anticoagulation during percutaneous coronary intervention (PCI) remains particularly challenging in high-risk and u...

Development and validation of an interpretable machine learning model for predicting in-hospital mortality among critically ill patients with liver cirrhosis.

This study aimed to develop and validate an interpretable machine learning model for early prediction of in-hospital mortality in critically ill patie...

Neoadjuvant Chemoradiotherapy on Postoperative Complications of Rectal Cancer: A Retrospective Study Integrating MRI Radiomics and Deep Learning.

Neoadjuvant chemoradiotherapy (nCRT) is standard for locally advanced rectal cancer but increases postoperative complication (POC) risks due to tissue...

Next-generation precision oncology in microsatellite stable colorectal cancer: integrated targeting beyond RAS and RAF.

The therapeutic landscape of colorectal cancer (CRC) has evolved with the identification of molecular subtypes, including mismatch repair-deficient/mi...

A machine learning approach to non-invasive prediction of hepatic decompensation in compensated advanced chronic liver disease: the CIRI model.

BACKGROUND & AIMS: Hepatic venous pressure gradient (HVPG) is the gold standard for assessment of prognosis in compensated advanced chronic liver dise...

Circulating multi-omic signature of disease severity and cholangiocarcinoma in primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with inflammatory bowel disease (IBD) that ca...

Activated Cancer-Associated Fibroblasts Are Associated with Immunosuppression and Poor Prognosis in Clear Cell Renal Cell Carcinoma.

INTRODUCTION: Clear cell renal cell carcinoma (ccRCC) exhibits substantial heterogeneity within its tumor microenvironment, contributing to variable c...

MAPPING THE MTOR PATHWAY IN LUNG TRANSPLANTATION: IS IT TIME FOR A BIOMARKER-DRIVEN PRECISION THERAPY?

Solid organ transplantation has revolutionized the treatment of end-stage diseases, yet long-term graft survival remains constrained by immune-mediate...

Integrated deep learning and multi-scale modeling for the discovery of pan-genotypic HCV NS5B polymerase inhibitors.

Chronic Hepatitis C Virus (HCV) infection remains a significant global health challenge, necessitating the development of pan-genotypic inhibitors to ...

Development and validation of a machine learning model for identifying liver fibrosis in MAFLD: a retrospective model development study.

BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD), as the most prevalent chronic liver disease globally, is closely related to ...

RRM2B is associated with low-level viremia during entecavir therapy in pediatric chronic hepatitis B and promotes profibrotic signaling in vitro.

BACKGROUND: Low-level viremia (LLV) during nucleos(t)ide analogue therapy for chronic hepatitis B (CHB) is clinically relevant, but its biological bas...

Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.

Epigenetic editing achieves durable gene silencing through targeted modification of chromatin and DNA methylation states without altering the genomic ...