Menopause

Evaluating bone density with ultrasonic backscatter: Leveraging time-frequency analyses and convolutional neural networks.

Osteoporosis is a disease characterized by decreased bone density and increased fracture risk. This study proposes a convolutional neural network (CNN) method for detecting changes in bone density using spectrograms or scalograms generated from ultrasonic backscatter signals of 55 human cancellous bone specimens from the proximal femur. After applying a simple grid search to optimize three CNN hyp...

AI Screening Tool Based on X-Rays Improves Early Detection of Decreased Bone Density in a Clinical Setting.

PURPOSE: Osteoporosis is an under-screened musculoskeletal disorder that results in diminished quality of life and significant burden to the healthcare system. We aimed to evaluate the ability of Rho, an artificial intelligence (AI) tool, to prospectively identify patients at-risk for low bone mineral density (BMD) from standard x-rays, its adoption rate by radiologists, and acceptance by primary ...

Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders.

We aimed to develop and validate a risk estimation model for developing bipolar-spectrum disorders (BSD) in psychiatrically hospitalized adolescents b...

An AI-based pipeline for osteoporosis/osteopenia prediction using hip radiographs.

OBJECTIVE: To develop and validate an artificial intelligence-based tool for the diagnosis of osteoporosis/osteopenia using hip radiographs. The tool ...

Nivolumab plus ipilimumab for potentially resectable hepatocellular carcinoma: Long-term efficacy and biomarker exploration.

BACKGROUND & AIMS: Immune checkpoint inhibitor-based combination therapy has demonstrated high objective response rates in patients with hepatocellula...

Artificial intelligence-assisted assessment of metabolic response to tebentafusp in metastatic uveal melanoma: a long axial field-of-view [18F]FDG PET/CT study.

PURPOSE: Tebentafusp has emerged as the first systemic therapy to significantly prolong survival in treatment-naïve HLA-A*02:01 + patients with unrese...

Flexible wearable medical devices: from material innovations and data processing to intelligent healthcare applications.

BACKGROUND: Flexible wearable medical devices drive healthcare transformation via non-invasive, real-time physiological monitoring and personalized ma...

Microbiome-metabolome generated bile acids gatekeep infliximab efficacy in Crohn's disease by licensing M1 suppression and Treg dominance.

INTRODUCTION: Despite the effectiveness of infliximab in treating Crohn's disease (CD), up to 40 % of patients fail to respond adequately. OBJECTIVES:...

Algal/bacterial membrane bioreactor for bioremediation of hazardous landfill leachate containing 1,4-dioxane: An artificial neural network modeling.

This study developed an artificial neural network (ANN) model to predict the 1,4-dioxane removal efficiency from hazardous landfill leachate treated b...

A Participatory Artificial Intelligence Driven Shift-Scheduling Application for Improving Sleep Among Shift-Working Caregivers: A 4-Month Non-Randomised Controlled Study With Cross-Over Design.

Here, we examine the effectiveness of a participatory artificial intelligence (AI)-driven shift-scheduling mobile application (which reflects the loca...

Deep learning algorithm for identifying osteopenia/osteoporosis using cervical radiography.

Due to symptomatic gait imbalance and a high incidence of falls, patients with cervical disease-including degenerative cervical myelopathy-have a sign...

A novel dual embedding few-shot learning approach for classifying bone loss using orthopantomogram radiographic notes.

BACKGROUND: Orthopantomograms (OPGs) are essential diagnostic tools in dental and maxillofacial care, providing a panoramic view of the jaws, teeth, a...

Value-Based Care in Orthopaedic Surgery: Outcomes, Costing, and Policy Updates.

➢ Strategic action following the measurement of outcomes in the context of cost allows for the reallocation of resources to value-adding interventions...

PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders.

INTRODUCTION: Cognitive behavioural therapy (CBT) serves as a first-line treatment for internalising disorders (ID), encompassing depressive, anxiety ...

Predicting antiretroviral therapy adherence status of adult HIV-positive patients using machine-learning Northwest, Ethiopia, 2025.

BACKGROUND: Adherence with Anti-Retroviral Therapy (ART) reduces viral load, as well as HIV-related morbidity and mortality. Despite the expanded avai...

Development of Artificial Intelligence-Assisted Lumbar and Femoral BMD Estimation System Using Anteroposterior Lumbar X-Ray Images.

The early detection and treatment of osteoporosis and prevention of fragility fractures are urgent societal issues. We developed an artificial intelli...

Integrated Nanopore and short-read RNA sequencing identifies dysregulation of METTL3- m6A modifications in endocrine therapy- sensitive and resistant breast cancer cells.

The role of epitranscriptomic changes in the development of acquired endocrine therapy (ET)- resistance in estrogen receptor α (ER) expressing breast ...

Exploring graph-based models for predicting active compounds against triple-negative breast cancer.

Breast cancer is among the most dominant and rapidly rising cancers, both in India and around the world. Triple-negative breast cancer (TNBC) is one o...

Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Despite advancements in treatment, prognosis for patients wi...

Improving prediction of fragility fractures in postmenopausal women using random forest.

Osteoporosis is a chronic disease characterized by a progressive decline in bone density and quality, leading to increased bone fragility and a higher...