Other Cancers

Development of an exploratory prediction model for preoperative CK19 expression in esophageal cancer driven by radiomics and machine learning.

BACKGROUND: Esophageal cancer ranks among the most lethal malignancies worldwide, particularly prevalent in the Guangdong-Chaoshan region of China due to regional dietary habits. Cytokeratin 19 (CK19) is an important immunohistochemical marker reflecting tumor invasiveness and metastatic potential; however, noninvasive preoperative prediction of CK19 expression remains unavailable. This study aime...

Morpho-functional plasticity of tumour-associated macrophages: linking cell shape, ultrastructure, and immune regulation in cancer.

Macrophages are highly adaptable immune cells that play dual roles in the tumor microenvironment (TME), either promoting or restraining tumor progression. Their polarization into M1 and M2 tumor-associated macrophage (TAM) phenotypes is classically defined by molecular and biochemical cues. Recent evidence shows that morphology also significantly influences the macrophage function and behavior. Th...

Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: From Oncologic Outcomes to Response-Adaptive Treatment De-escalation.

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) are associated with poor 5-year survival and substantial treatment-related morbidity. Neoadj...

Rapid autofluorescence based 3D optical imaging of the pancreatic cancer milieu at mesoscopic scale - stain-free volumetric segmentation.

Although major advances have been made in the field of mesoscopic imaging and associated tissue clearing protocols, these applications are greatly cha...

Spatially resolved single cell analysis suggests an APOE NCF1 associated immunosuppressive niche and its prognostic signature in thyroid cancer.

BACKGROUND: Thyroid carcinoma (TC) presents a rising global incidence, with a subset of cases progressing aggressively despite standard therapies. The...

Integrating machine learning and spatiotemporal transcriptomics to build a diagnostic model for osteosarcoma metastasis and to decipher the role of necroptosis genes.

OBJECTIVE: To develop a diagnostic model for osteosarcoma metastasis and elucidate the spatiotemporal role of necroptosis genes. METHODS: Multi-omics ...

Techniques and outcomes review of the endoscopic management of gastrointestinal bleeding.

INTRODUCTION: Gastrointestinal (GI) bleeding is a frequent and potentially life-threatening emergency that imposes a substantial healthcare burden wor...

Exploratory Comparison of Meld, Meld-Na, and Meld 3.0 Scores for Prognostic Assessment at Diagnosis in Hepatocellular Carcinoma Using Machine Learning Approaches.

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver tumor. Despite efforts to mitigate risk factors and implement surveillance...

Screening of the key gene PAMR1 in breast cancer and its immunological and pharmacogenomic characteristics.

Breast cancer (BC) is a highly heterogeneous malignancy with a complex pathogenesis involving multiple molecular pathways and cellular interactions. T...

Deep learning-based cervical cancer T-staging using MRI: multi-structure segmentation and classification.

AIMS: Cervical cancer has high incidence and mortality, seriously threatening women's survival and quality of life. Radiologists currently rely mainly...

What's next for VI-RADS? Updates and future perspectives from the ACR VI-RADS steering committee.

Since the introduction of the Vesical Imaging-Reporting and Data System (VI-RADS), MRI has become an important imaging modality in the management of p...

ABCC2 as a novel therapeutic target in lung adenocarcinoma: a machine learning-driven discovery linking ammonia metabolism to prognosis and drug resistance.

BACKGROUND: Ammonia, long regarded as a metabolic waste product, has recently been recognized as a pivotal oncometabolite in the tumor microenvironmen...

Decoding the microbiome: artificial intelligence-targeted gut microenvironment breakthroughs in personalized cancer therapy.

The gut microbiome functions as a key regulator of tumorigenesis and progression, thereby modulating tumor development and treatment outcomes (includi...

FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression.

Hypoxia is a hallmark of oral squamous cell carcinoma (OSCC) and plays a critical role in driving tumor progression. However, the mechanisms by which ...

Proteomic and transcriptomic analyses identify the role of RBM25 in the malignant progression of glioma.

Glioma is a primary tumor derived from central nervous system glial cells. RNA binding motif protein 25 (RBM25) has been implicated in glioma progress...

From Technological Innovation to Clinical Translation: Progress and Challenges in 3D Bioprinting for the Development of Breast Cancer Bone Metastasis Models.

The construction of 3D in vitro tumor models centered on bioprinting technology represents one of the most anticipated interdisciplinary innovations a...

Two-stage deep learning networks for diagnosing and staging membranous glomerulonephritis from electron microscopy images.

PURPOSE: The purpose of this study was to use transmission electron miscroscopy images to develop a deep-learning-based artificial intelligence model ...

Deep Learning-Based Diagnosis of Parotid Gland Tumors on CT Images: A Multi-view Approach for Preoperative Differentiation of Benign and Malignant Lesions.

BACKGROUND: Accurate preoperative differentiation between benign and malignant parotid gland tumors is essential for guiding surgical planning and tre...

Artificial Intelligence for Sleep Instability and Motor Phenotyping: Clinical Translation Beyond Sleep Staging.

Sleep medicine has rapidly adopted artificial intelligence, but most applications still prioritize automated sleep staging or single summary indices, ...

A macrophage-related efferocytosis-based two-gene prognostic model for acute myeloid leukemia identified by multi-omics and machine learning.

Background Acute myeloid leukemia (AML) remains a lethal hematologic malignancy with high heterogeneity. Macrophage-mediated efferocytosis in the tumo...