Alzheimer's & dementia : the journal of the Alzheimer's Association
May 1, 2025
INTRODUCTION: Alzheimer's disease (AD), a leading cause of dementia, requires early detection for effective intervention. This study employs AI to analyze multimodal datasets, including clinical, biomarker, and neuroimaging data, using hybrid deep le...
Alzheimer's & dementia : the journal of the Alzheimer's Association
May 1, 2025
INTRODUCTION: Identifying individuals with dementia is crucial for prevalence estimation and service planning, but reliable, scalable methods are lacking. We developed novel set algorithms using both structured and unstructured electronic health reco...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Mar 1, 2025
BACKGROUND: Integrating non-invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological tests in estim...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Mar 1, 2025
INTRODUCTION: Cerebral amyloid angiopathy (CAA) is a cerebrovascular condition, the severity of which can only be determined post mortem. Here, we developed machine learning models, the Florey CAA Score (FCAAS), to predict CAA severity (none/mild/mod...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Feb 1, 2025
INTRODUCTION: Cognitive decline has become a growing public concern, yet large-scale exposure data identifying the contributing factors remain limited.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Feb 1, 2025
INTRODUCTION: Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Dec 1, 2022
BACKGROUND: Persons living with dementia and their care partners place a high value on aging in place and maintaining independence. Socially assistive robots - embodied characters or pets that provide companionship and aid through social interaction ...