AI Medical Compendium Journal:
International journal of biological macromolecules

Showing 51 to 60 of 120 articles

PredIDR: Accurate prediction of protein intrinsic disorder regions using deep convolutional neural network.

International journal of biological macromolecules
The involvement of protein intrinsic disorder in essential biological processes, it is well known in structural biology. However, experimental methods for detecting intrinsic structural disorder and directly measuring highly dynamic behavior of prote...

DeepKlapred: A deep learning framework for identifying protein lysine lactylation sites via multi-view feature fusion.

International journal of biological macromolecules
Lysine lactylation (Kla) is a post-translational modification (PTM) that holds significant importance in the regulation of various biological processes. While traditional experimental methods are highly accurate for identifying Kla sites, they are bo...

Deciphering Cas9 specificity: Role of domain dynamics and RNA:DNA hybrid interactions revealed through machine learning and accelerated molecular simulations.

International journal of biological macromolecules
CRISPR/Cas9 technology is widely used for gene editing, but off-targeting still remains a major concern in therapeutic applications. Although Cas9 variants with better mismatch discrimination have been developed, they have significantly lower rates o...

Targeting mitochondria in Cancer therapy: Machine learning analysis of hyaluronic acid-based drug delivery systems.

International journal of biological macromolecules
BACKGROUND: Mitochondrial alterations play a crucial role in the development and progression of cancer. Dysfunctional mitochondria contribute to the acquisition of key hallmarks of cancer, including sustained proliferative signaling, evasion of growt...

SDC4 protein action and related key genes in nonhealing diabetic foot ulcers based on bioinformatics analysis and machine learning.

International journal of biological macromolecules
Diabetic foot ulcers (DFU) is a complication associated with diabetes characterised by high morbidity, disability, and mortality, involving chronic inflammation and infiltration of multiple immune cells. We aimed to identify the critical genes in non...

Machine learning-enhanced modeling and characterization for optimizing dietary Fiber production from Highland barley bran.

International journal of biological macromolecules
This study investigated the modification of highland barley bran through co-fermentation of Lactobacillus bulgaricus and Kluyveromyces marxianus, and developed a dynamic prediction model for DF content under these co-fermentation conditions using mac...

Small molecule inhibitors of IL-1R1/IL-1β interaction identified via transfer machine learning QSAR modelling.

International journal of biological macromolecules
The human interleukin-1 receptor I (IL-1R1) is a cytokine receptor recognized by interleukin 1β (IL-1β), among other cytokines. Over activation of IL-1R1 has been implicated in various inflammatory conditions. This research aims to identify small-mol...

Identification of ferroptosis-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches.

International journal of biological macromolecules
Ferroptosis has emerged as a critical mechanism in the development and progression of various tumors, particularly diffuse large B-cell lymphoma (DLBCL). However, the thorough characterization of ferroptosis-related genes in DLBCL remains inadequatel...

Essential blood molecular signature for progression of sepsis-induced acute lung injury: Integrated bioinformatic, single-cell RNA Seq and machine learning analysis.

International journal of biological macromolecules
In this study, we aimed to identify an essential blood molecular signature for chacterizing the progression of sepsis-induced acute lung injury using integrated bioinformatic and machine learning analysis. The results showed that a total of 88 functi...

Biosorption of cobalt and chromium from wastewater using manganese dioxide and iron oxide nanoparticles loaded on cellulose-based biochar: Modeling and optimization with machine learning (artificial neural network).

International journal of biological macromolecules
In this study, two nanomaterials with excellent adsorption capacities were developed to remove heavy metals efficiently from wastewater. Manganese dioxide MnO nanoparticles and iron oxide FeO nanoparticles were successfully synthesized using cassava ...