AIMC Journal:
International journal of molecular sciences

Showing 241 to 250 of 423 articles

Identifying Drug Targets of Oral Squamous Cell Carcinoma through a Systems Biology Method and Genome-Wide Microarray Data for Drug Discovery by Deep Learning and Drug Design Specifications.

International journal of molecular sciences Sep 8, 2022
In this study, we provide a systems biology method to investigate the carcinogenic mechanism of oral squamous cell carcinoma (OSCC) in order to identify some important biomarkers as drug targets. Further, a systematic drug discovery method with a dee...
Humans Biomarkers Drug Design Drug Discovery Carcinoma, Squamous Cell Biomarkers, Tumor Gefitinib Metformin Squamous Cell Carcinoma of Head and Neck Head and Neck Neoplasms NF-kappa B Mouth Neoplasms Systems Biology Gene Expression Regulation, Neoplastic Deep Learning
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A Study on the Prediction of Cancer Using Whole-Genome Data and Deep Learning.

International journal of molecular sciences Sep 8, 2022
The number of patients diagnosed with cancer continues to increasingly rise, and has nearly doubled in 20 years. Therefore, predicting cancer occurrence has a significant impact on reducing medical costs, and preventing cancer early can increase surv...
Humans Reproducibility of Results Deep Learning Neoplasms ROC Curve
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A Multifunctional Light-Driven Swimming Soft Robot for Various Application Scenarios.

International journal of molecular sciences Aug 25, 2022
The locomotor behavior of creatures in nature can bring a lot of inspiration for the fabrication of soft actuators. In this paper, we fabricated a bionic light-driven swimming soft robot that can perform grasping of tiny objects and achieve the task ...
Robotics Hydrogels Nanotubes, Carbon Temperature Swimming
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Neural Networks Reveal the Impact of the Vibrational Dynamics in the Prediction of the Long-Time Mobility of Molecular Glassformers.

International journal of molecular sciences Aug 18, 2022
Two neural networks (NN) are designed to predict the particle mobility of a molecular glassformer in a wide time window ranging from vibrational dynamics to structural relaxation. Both NNs are trained by information concerning the local structure of ...
Vibration Neural Networks, Computer
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From Classic to Modern Prognostic Biomarkers in Patients with Acute Myocardial Infarction.

International journal of molecular sciences Aug 15, 2022
Despite all the important advances in its diagnosis and treatment, acute myocardial infarction (AMI) is still one of the most prominent causes of morbidity and mortality worldwide. Early identification of patients at high risk of poor outcomes throug...
Myocardial Infarction Artificial Intelligence Biomarkers Prognosis Risk Assessment Humans
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CSatDTA: Prediction of Drug-Target Binding Affinity Using Convolution Model with Self-Attention.

International journal of molecular sciences Jul 30, 2022
Drug discovery, which aids to identify potential novel treatments, entails a broad range of fields of science, including chemistry, pharmacology, and biology. In the early stages of drug development, predicting drug-target affinity is crucial. The pr...
Drug Discovery Drug Development Neural Networks, Computer
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Panoramic Manifold Projection (Panoramap) for Single-Cell Data Dimensionality Reduction and Visualization.

International journal of molecular sciences Jul 14, 2022
Nonlinear dimensionality reduction (NLDR) methods such as t-Distributed Stochastic Neighbour Embedding (t-SNE) and Uniform Manifold Approximation and Projection (UMAP) have been widely used for biological data exploration, especially in single-cell a...
Algorithms Single-Cell Analysis Neural Networks, Computer
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Structural Bioinformatics and Deep Learning of Metalloproteins: Recent Advances and Applications.

International journal of molecular sciences Jul 12, 2022
All living organisms require metal ions for their energy production and metabolic and biosynthetic processes. Within cells, the metal ions involved in the formation of adducts interact with metabolites and macromolecules (proteins and nucleic acids)....
Deep Learning Metals Computational Biology Databases, Protein Metalloproteins Binding Sites
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Development of Deep-Learning-Based Single-Molecule Localization Image Analysis.

International journal of molecular sciences Jun 21, 2022
Recent developments in super-resolution fluorescence microscopic techniques (SRM) have allowed for nanoscale imaging that greatly facilitates our understanding of nanostructures. However, the performance of single-molecule localization microscopy (SM...
Microscopy, Fluorescence Single Molecule Imaging Deep Learning Algorithms Image Processing, Computer-Assisted
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Systems Drug Discovery for Diffuse Large B Cell Lymphoma Based on Pathogenic Molecular Mechanism via Big Data Mining and Deep Learning Method.

International journal of molecular sciences Jun 16, 2022
Diffuse large B cell lymphoma (DLBCL) is an aggressive heterogeneous disease. The most common subtypes of DLBCL include germinal center b-cell (GCB) type and activated b-cell (ABC) type. To learn more about the pathogenesis of two DLBCL subtypes (i.e...
Deep Learning Data Mining Drug Discovery Humans Lymphoma, Large B-Cell, Diffuse Germinal Center
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