Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Aug 12, 2023
BRCA1 and BRCA2 genes play a crucial role in repairing DNA double-strand breaks through homologous recombination. Their mutations represent a significant proportion of homologous recombination deficiency and are a reliable effective predictor of sens...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Jul 31, 2023
Deep learning systems (DLSs) have been developed for the histopathological assessment of various types of tumors, but none are suitable for differential diagnosis between follicular thyroid carcinoma (FTC) and follicular adenoma (FA). Furthermore, wh...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Jun 19, 2023
Phosphatase and tensin homolog (PTEN) loss is associated with adverse outcomes in prostate cancer and can be measured via immunohistochemistry. The purpose of the study was to establish the clinical application of an in-house developed artificial int...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Jun 10, 2023
Microscopic examination of prostate cancer has failed to reveal a reproducible association between molecular and morphologic features. However, deep-learning algorithms trained on hematoxylin and eosin (H&E)-stained whole slide images (WSI) may outpe...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
May 30, 2023
Tumor budding (TB), the presence of single cells or small clusters of up to 4 tumor cells at the invasive front of colorectal cancer (CRC), is a proven risk factor for adverse outcomes. International definitions are necessary to reduce interobserver ...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
May 4, 2023
Although programmed death-(ligand) 1 (PD-(L)1) inhibitors are marked by durable efficacy in patients with non-small cell lung cancer (NSCLC), approximately 60% of the patients still suffer from recurrence and metastasis after PD-(L)1 inhibitor treatm...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Apr 24, 2023
Microscopic examination of pathology slides is essential to disease diagnosis and biomedical research. However, traditional manual examination of tissue slides is laborious and subjective. Tumor whole-slide image (WSI) scanning is becoming part of ro...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Mar 15, 2023
Differential classification of prostate cancer grade group (GG) 2 and 3 tumors remains challenging, likely because of the subjective quantification of the percentage of Gleason pattern 4 (%GP4). Artificial intelligence assessment of %GP4 may improve ...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Feb 2, 2023
Screening of lymph node metastases in colorectal cancer (CRC) can be a cumbersome task, but it is amenable to artificial intelligence (AI)-assisted diagnostic solution. Here, we propose a deep learning-based workflow for the evaluation of CRC lymph n...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Jan 11, 2023
Training machine learning models for artificial intelligence (AI) applications in pathology often requires extensive annotation by human experts, but there is little guidance on the subject. In this work, we aimed to describe our experience and provi...