AI Medical Compendium Journal:
Nature medicine

Showing 1 to 10 of 157 articles

Benchmark evaluation of DeepSeek large language models in clinical decision-making.

Nature medicine
Large language models (LLMs) are increasingly transforming medical applications. However, proprietary models such as GPT-4o face significant barriers to clinical adoption because they cannot be deployed on site within healthcare institutions, making ...

Artificial intelligence for individualized treatment of persistent atrial fibrillation: a randomized controlled trial.

Nature medicine
Although pulmonary vein isolation (PVI) has become the cornerstone ablation procedure for atrial fibrillation (AF), the optimal ablation procedure for persistent and long-standing persistent AF remains elusive. Targeting spatio-temporal electrogram d...

Artificial intelligence for direct-to-physician reporting of ambulatory electrocardiography.

Nature medicine
Developments in ambulatory electrocardiogram (ECG) technology have led to vast amounts of ECG data that currently need to be interpreted by human technicians. Here we tested an artificial intelligence (AI) algorithm for direct-to-physician reporting ...

GPT-4 assistance for improvement of physician performance on patient care tasks: a randomized controlled trial.

Nature medicine
While large language models (LLMs) have shown promise in diagnostic reasoning, their impact on management reasoning, which involves balancing treatment decisions and testing strategies while managing risk, is unknown. This prospective, randomized, co...

Artificial intelligence in drug development.

Nature medicine
Drug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation. The advent of artificial intelligence (AI) technologies, particularly emerging large languag...

Nationwide real-world implementation of AI for cancer detection in population-based mammography screening.

Nature medicine
Artificial intelligence (AI) in mammography screening has shown promise in retrospective evaluations, but few prospective studies exist. PRAIM is an observational, multicenter, real-world, noninferiority, implementation study comparing the performanc...

Evaluating generalizability of oncology trial results to real-world patients using machine learning-based trial emulations.

Nature medicine
Randomized controlled trials (RCTs) evaluating anti-cancer agents often lack generalizability to real-world oncology patients. Although restrictive eligibility criteria contribute to this issue, the role of selection bias related to prognostic risk r...

International multicenter validation of AI-driven ultrasound detection of ovarian cancer.

Nature medicine
Ovarian lesions are common and often incidentally detected. A critical shortage of expert ultrasound examiners has raised concerns of unnecessary interventions and delayed cancer diagnoses. Deep learning has shown promising results in the detection o...

Self-improving generative foundation model for synthetic medical image generation and clinical applications.

Nature medicine
In many clinical and research settings, the scarcity of high-quality medical imaging datasets has hampered the potential of artificial intelligence (AI) clinical applications. This issue is particularly pronounced in less common conditions, underrepr...