Journal of chemical information and modeling
Jul 14, 2025
DNA N6-methyladenine (6mA) is a pivotal DNA modification integral to various biological processes, yet its exact regulatory role in eukaryotes is still unclear and controversial due to its sparsity, limitations in detection technologies, and complex ...
Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) poses significant therapeutic challenges due to heterogeneous patient outcomes. This study aimed to evaluate the efficacy of the ibrutinib plus R-ICE regimen and to leverage explainable mac...
BACKGROUND: Adenine base editors (ABEs) enable the conversion of A•T to G•C base pairs. Since the sequence of the target locus influences base editing efficiency, efforts have been made to develop computational models that can predict base editing ou...
BACKGROUND: N6-methyladenine (6mA) is an important DNA methylation modification that serves a crucial function in various biological activities. Accurate prediction of 6mA sites is essential for elucidating its biological function and underlying mech...
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Nov 1, 2015
OBJECTIVE: To establish a method for simultaneous determination of nucleosides and nucleobases in natural, cultured and tissue culture Anoectochilus roxburghii by high performance liquid chromatography-electrospray ionization/ion trap mass spectromet...
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