AIMC Topic: Aged

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Opportunistic computed tomography (CT) assessment of osteoporosis in patients undergoing transcatheter aortic valve replacement (TAVR).

Archives of osteoporosis
UNLABELLED: CT-based opportunistic screening using artificial intelligence finds a high prevalence (43%) of osteoporosis in CT scans obtained for planning of transcatheter aortic valve replacement. Thus, opportunistic screening may be a cost-effectiv...

Predicting postprandial glucose excursions to personalize dietary interventions for type-2 diabetes management.

Scientific reports
Elevated postprandial glucose levels present a global epidemic and a major challenge in type-2 diabetes (T2D) management. A key barrier to developing effective dietary interventions for T2D management is the wide inter-individual variation in glycemi...

Lectin-affinity glycosylation pattern analysis of plasma extracellular vesicles: An all-in-one clinical assessment for gastric cancer diagnosis and treatment.

Cancer letters
Extracellular vesicles (EVs) exhibit extensive glycosylation modifications, which are promising biomarkers for gastric cancer (GC). However, EV glycomics and the potential application of EV glycosylation patterns in liquid biopsy remain largely unexp...

Multimodal neuroimaging unveils basal forebrain-limbic system circuit dysregulation in cognitive impairment with depression: a pathway to early diagnosis and intervention.

The journal of prevention of Alzheimer's disease
BACKGROUND: Alzheimer's disease (AD) frequently co-occurs with depressive symptoms, exacerbating both cognitive decline and clinical complexity, yet the neural substrates linking this co-occurrence remain poorly understood. We aimed to investigate th...

Developing the CAM-BERT: Enhancing delirium screening in hospitalized older adults using natural language processing.

Computers in biology and medicine
BACKGROUND: Delirium is a common condition affecting hospitalized older adults, often leading to adverse outcomes. Nevertheless, delirium frequently goes unrecognized due to various clinical and systemic challenges. We aimed to develop and evaluate a...

Comparison of synthetic LGE with optimal inversion time vs. conventional LGE via representation learning: Quantification of Bias in Population Analysis.

Computers in biology and medicine
PURPOSE: Late Gadolinium Enhancement (LGE) images are crucial elements of CMR protocols for evaluating myocardial infarct (MI) severity and size. However, these images rely on signal intensity changes and manual inversion time (TI) settings, leading ...

Machine Learning Prediction of Financial Toxicity in Patients with Resected Lung Cancer.

Journal of the American College of Surgeons
BACKGROUND: Financial toxicity (FT) refers to the financial stress and detrimental impact on quality of life experienced by patients due to treatment cost. In patients with resected lung cancer (LC), we sought to identify those at risk of developing ...

Conditional GAN performs better than orthopedic surgeon in virtual reduction of femoral neck fracture.

BMC musculoskeletal disorders
OBJECTIVE: Satisfied reduction of fracture is hard to achieve. The purpose of this study is to develop a virtual fracture reduction technique using conditional GAN (Generative Adversarial Network), and evaluate its performance in simulating and guidi...

An end-to-end interpretable machine-learning-based framework for early-stage diagnosis of gallbladder cancer using multi-modality medical data.

BMC cancer
BACKGROUND: The accurate early-stage diagnosis of gallbladder cancer (GBC) is regarded as one of the major challenges in the field of oncology. However, few studies have focused on the comprehensive classification of GBC based on multiple modalities....

Multi-tissue Methylation Analysis of Alzheimer's Disease: Insights into Pathways, Modules, and Key Genes.

Journal of molecular neuroscience : MN
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...