AIMC Topic: Analgesics, Opioid

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Exchanging expertise and constructing boundaries: The development of a transnational knowledge network around heroin-assisted treatment.

The International journal on drug policy
Over the last 20 years, supervised injectable and inhalable heroin prescribing has been developed, tested and in some cases introduced as a second line treatment for limited groups of entrenched heroin users in a number of European countries and Cana...

Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.

Pain medicine (Malden, Mass.)
OBJECTIVES: A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER® [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the intranasal abuse potential ...

Machine learning on encephalographic activity may predict opioid analgesia.

European journal of pain (London, England)
BACKGROUND: Opioids are used for the treatment of pain. However, 30-50% of patients have insufficient effect to the opioid initially selected by the physician, and there is an urgent need for biomarkers to select responders to the most appropriate dr...

Transversus abdominis plane (TAP) block after robot-assisted laparoscopic hysterectomy: a randomised clinical trial.

Acta anaesthesiologica Scandinavica
BACKGROUND: Transversus abdominis plane (TAP) block is widely used as a part of pain management after various abdominal surgeries. We evaluated the effect of TAP block as an add-on to the routine analgesic regimen in patients undergoing robot-assiste...

Transversus abdominis plane block in robotic gynecologic oncology: a randomized, placebo-controlled trial.

Gynecologic oncology
OBJECTIVE: Although robotic surgery decreases pain compared to laparotomy, postoperative pain can be a concern near the site of a larger assistant trocar site. The aim of this study was to determine the efficacy of transversus abdominis plane (TAP) b...

Investigating heterogeneous effects of an expanded methadone access policy with opioid treatment program retention: a Rhode Island population-based retrospective cohort study.

American journal of epidemiology
Following federal regulatory changes during the COVID-19 pandemic, Rhode Island expanded methadone access for opioid treatment programs (OTPs) in March 2020. The policy, which permitted take-home dosing for patients, contrasted with longstanding rest...

Chronic Pain Prevalence, Opioid Use, and Primary Care Provider Opioid Prescription Patterns in the U.S. from 2017 to 2019 Derived from Medicaid Claims Data.

Studies in health technology and informatics
Chronic non-cancer pain (CNCP) is a major health concern in the United States, incurring substantial healthcare costs and frequently requiring opioid therapy in primary care. This retrospective cross-sectional study used Medicaid claims data from six...

The future of target-controlled infusion and new pharmacokinetic models.

Current opinion in anaesthesiology
PURPOSE OF REVIEW: To summarize recent developments in the understanding of the pharmacology of the hypnotic and opioid drugs, with relevance to target-controlled infusions and newer pharmacokinetic models.