AIMC Topic: Analgesics, Opioid
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The future of target-controlled infusion and new pharmacokinetic models.
Current opinion in anaesthesiology
Aug 1, 2025
PURPOSE OF REVIEW: To summarize recent developments in the understanding of the pharmacology of the hypnotic and opioid drugs, with relevance to target-controlled infusions and newer pharmacokinetic models.
External Validation of an Algorithm to Guide Opioid Administration at the End of Surgery-Protocol for an Observational Cohort Study of the OPIAID Algorithm.
Acta anaesthesiologica Scandinavica
Jul 1, 2025
BACKGROUND: Despite advances in pain management, inadequate pain relief and opioid-related adverse events remain common challenges in perioperative care, often contributing to prolonged recovery and reduced quality of life. The perioperative opioid a...
Identification and designing an analgesic opioid cyclic peptide from Defensin 4 of Mesobuthus martensii Karsch scorpion venom with more effectiveness than morphine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Jul 1, 2025
Considering the limitations of use and side effects of existing analgesics, the discovery of new analgesics is necessary. Venoms of organisms are an important source of analgesic peptides. In this study, using computational biology methods such as mo...
Automating the Addiction Behaviors Checklist for Problematic Opioid Use Identification.
JAMA psychiatry
Jun 1, 2025
IMPORTANCE: Individuals whose chronic pain is managed with opioids are at high risk of developing an opioid use disorder. Electronic health records (EHR) allow large-scale studies to identify a continuum of problematic opioid use, including opioid us...
Predicting postoperative chronic opioid use with fair machine learning models integrating multi-modal data sources: a demonstration of ethical machine learning in healthcare.
Journal of the American Medical Informatics Association : JAMIA
Jun 1, 2025
OBJECTIVE: Building upon our previous work on predicting chronic opioid use using electronic health records (EHR) and wearable data, this study leveraged the Health Equity Across the AI Lifecycle (HEAAL) framework to (a) fine tune the previously buil...
Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression.
Function (Oxford, England)
May 19, 2025
Previous studies reported that opioids depress breathing by inhibiting respiratory neural networks in the brainstem. The effects of opioids on sensory inputs regulating breathing are less studied. This study examined the effects of fentanyl and sufen...
Linguistic Markers of Pain Communication on X (Formerly Twitter) in US States With High and Low Opioid Mortality: Machine Learning and Semantic Network Analysis.
Journal of medical Internet research
May 13, 2025
BACKGROUND: The opioid epidemic in the United States remains a major public health concern, with opioid-related deaths increasing more than 8-fold since 1999. Chronic pain, affecting 1 in 5 US adults, is a key contributor to opioid use and misuse. Wh...
Identifying high-dose opioid prescription risks using machine learning: A focus on sociodemographic characteristics.
Journal of opioid management
Jan 1, 2025
OBJECTIVE: The objective of this study was to leverage machine learning techniques to analyze administrative claims and socioeconomic data, with the aim of identifying and interpreting the risk factors associated with high-dose opioid prescribing.
Identification of Subphenotypes of Opioid Use Disorder Using Unsupervised Machine Learning.
Studies in health technology and informatics
May 18, 2023
This paper aimed to detect the latent clusters of patients with opioid use disorder and to identify the risk factors affecting drug misuse using unsupervised machine learning. The cluster with the highest proportion of successful treatment outcomes w...
Analgesic efficacy of two different volumes of local anaesthetics in ultrasound-guided modified approach to the thoracolumbar interfascial plane block in patients undergoing lumbar spine surgeries: a randomized controlled trial.
Anaesthesiology intensive therapy
Jan 1, 2023
INTRODUCTION: There is a lack of clarity regarding the ideal local anaesthetic volume for modified thoracolumbar interfascial plane (mTLIP) block. This study was designed to investigate the analgesic efficacy of two different volumes of bupivacaine 0...
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