Journal of agricultural and food chemistry
Nov 12, 2025
Omics technologies are revolutionizing food and nutrition research by enabling high-throughput analysis of food components and microorganisms and revealing the intricate relationships between food and human health. Machine learning (ML) methods are p...
BACKGROUND: Genomic Best Linear Unbiased Prediction (GBLUP) assumes that all SNPs contribute equally to genetic variance, including those with minimal impact, limiting its accuracy. A major challenge in animal breeding is to develop more scientific m...
Interindividual variation in biological responses to physiological stimuli is a widely recognized phenomenon. However, effective computational tools for identifying the individual-specific mechanisms remain limited. We present the bioreaction-variati...
Cancer immunology, immunotherapy : CII
Nov 12, 2025
Matrix stiffness is a defining feature of pancreatic ductal adenocarcinoma (PDAC) and drives malignant progression through mechanisms that remain poorly understood. Using an ensemble machine learning approach, we integrated multiomics data from 886 p...
The rapid development of spatial transcriptomics (ST) has made it possible to effectively integrate gene expression and spatial information of cells and accurately identify spatial domains. A large number of deep learning (DL)-based methods have been...
Journal of controlled release : official journal of the Controlled Release Society
Nov 8, 2025
The human immune system defends against pathogens, regulates inflammation, and supports tissue repair, but overactivity or dysregulation can compromise these functions. While wearable devices have been explored for immune modulation, conventional des...
Journal of cancer research and clinical oncology
Nov 8, 2025
AIM: Vasculogenic mimicry (VM), a process in which cancer cells form endothelial cell-independent vascular networks, is a hallmark of tumor aggressiveness in lung adenocarcinoma (LUAD) and supports tumor growth and metastasis. This study aims to iden...
Mass spectrometry imaging (MSI) is a powerful multiplexed biochemical imaging modality. It relies on raster scanning for localized data acquisition, which can be time-consuming, limiting applications of high-resolution tissue mapping and 3D reconstru...
Biomedical materials (Bristol, England)
Nov 7, 2025
Cancer is among the major causes of mortality, responsible for approximately 15% of all deaths worldwide. Despite remarkable progress in modern medicine, it remains a significant global health challenge. Nevertheless, conventional therapies such as c...
Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammator...
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