AIMC Topic: Animals
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Artificial intelligence-driven discovery of YH395A: A novel TGFβR1 inhibitor with potent anti-tumor activity against triple-negative breast cancer.
Cell communication and signaling : CCS
Jul 8, 2025
Characterized by high malignancy and limited treatment efficacy, triple-negative breast cancer (TNBC) remains a clinically challenging subtype within breast cancer classifications, marked by rapid progression and high mortality. Abnormal activation o...
The application and discovery of animal models in enterovirus research.
Archives of virology
Jul 8, 2025
Enterovirus infection remains a significant global public health challenge, causing severe diseases such as hand, foot, and mouth disease (HFMD) and meningitis. Given the current lack of effective broad-spectrum antiviral therapies, it is important t...
Interpretability-guided RNA N-methyladenosine modification site prediction with invertible neural networks.
Communications biology
Jul 8, 2025
As one of the most common and abundant post-transcriptional modifications, N-methyladenosine (mA) has been extensively studied for its essential regulatory role in gene expression and cell functions. The location of mA RNA modification sites, however...
Diverse prey capture strategies in teleost larvae.
eLife
Jul 8, 2025
Animal behavior is adapted to the sensory environment in which it evolved, while also being constrained by physical limits, evolutionary history, and developmental trajectories. The hunting behavior of larval zebrafish (), a cyprinid native to stream...
Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier.
Journal of nanobiotechnology
Jul 8, 2025
The blood-brain barrier (BBB) poses a major challenge to the effective delivery of therapeutic agents for the treatment of central nervous system (CNS) disorders. The integration of cell membrane engineering with nanotechnology has recently enabled t...
Predictive models of influenza A virus lethal disease yield insights from ferret respiratory tract and brain tissues.
Scientific reports
Jul 8, 2025
Collection of systemic tissues from influenza A virus (IAV)-infected ferrets at a fixed timepoint post-inoculation represents a frequent component of risk assessment activities to assess the capacity of IAV to replicate systemically. However, few stu...
Gut microbiota composition is related to anxiety and aggression scores in companion dogs.
Scientific reports
Jul 8, 2025
There is mounting evidence for a link between behaviour and the gut microbiome in animal and human health. However, the role of the gut microbiome in the development and severity of behavioural issues in companion dogs is not yet fully understood. He...
Cellular senescence in renal ischemia-reperfusion injury.
Chinese medical journal
Jul 7, 2025
Acute kidney injury (AKI) affects more than 20% of hospitalized patients and is a significant contributor to morbidity and mortality, primarily due to ischemia-reperfusion injury (IRI), which is one of the leading causes of AKI. IRI not only exacerba...
Beyond the human touch: A critical review of the promise and challenges of animal- and robot-assisted therapy in loneliness and mental healthcare.
Asian journal of psychiatry
Jul 7, 2025
Mental health disorders, including depression, anxiety, post-traumatic stress disorder, and dementia, are increasingly recognized as exacerbated by social isolation and loneliness, prompting growing interest in Artificial Intelligence (AI) driven and...
Combining the NanaPPI Toolbox and AI-Driven Virtual Inhibitor Screening for the p53-MDM2 Interaction.
Analytical chemistry
Jul 7, 2025
High-throughput screening for inhibitors of protein-protein interactions (PPIs) provides vital information for therapeutic intervention in diseases driven by aberrant PPIs. Traditionally, the discovery of PPI inhibitors involves sequential steps: in ...
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