AIMC Topic: Animals

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A machine learning multimodal profiling of Per- and Polyfluoroalkyls (PFAS) distribution across animal species organs via clustering and dimensionality reduction techniques.

Food research international (Ottawa, Ont.)
Per- and polyfluoroalkyl substances (PFAS) contamination in aquatic and terrestrial organisms poses significant environmental and health risks. This study quantified 15 PFAS compounds across various tissues (liver, kidney, gill, muscle, skin, lung, b...

Automated device for rapid sample cooling via controlled submersion.

Cryobiology
An automated device is described which enables programmable submersion in liquid nitrogen to enable rapid specimen cooling for vitrification applications. The device presented here is low-cost, portable, and compatible with a range of cryogenic conta...

Evolution of gene regulatory networks in insects.

Current opinion in insect science
Changes in gene regulatory networks (GRNs) underlying the evolution of traits have been intensively studied, with insects providing excellent model cases. In studies using Drosophila, butterflies, and other insects, several well-known cases have show...

Molecular glue meets antibody: next-generation antibody-drug conjugates.

Trends in pharmacological sciences
Antibody-drug conjugates (ADCs) have revolutionized oncology by enabling the delivery of cytotoxic agents. However, persistent limitations in payload diversity and emerging drug-resistance mechanisms have spurred investigations into innovative payloa...

AutoFE-Pointer: Auto-weighted feature extractor based on pointer network for DNA methylation prediction.

International journal of biological macromolecules
DNA methylation is a critical epigenetic modification that plays a central role in gene regulation, cellular differentiation, and the development of various diseases, including cancers. Aberrant methylation patterns have emerged as both biomarkers an...

Assessing amyloid fibrils and amorphous aggregates: A review.

International journal of biological macromolecules
Protein misfolding and aggregation play a central role in the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. These aggregates manifest either as structured amyloid fibrils enriched in β-sheet conformations or as irregu...

Deep learning meets marine biology: Optimized fused features and LIME-driven insights for automated plankton classification.

Computers in biology and medicine
Plankton are microorganisms that play an important role in marine food webs as primary producers in the trophic web. Traditional plankton identification methods using manual microscopy and sampling are time-consuming, labor-intensive, and prone to er...

A comprehensive update on the application of high-throughput fluorescence imaging for novel drug discovery.

Expert opinion on drug discovery
INTRODUCTION: High-throughput fluorescence imaging (HTFI) is revolutionizing drug discovery by enabling rapid and precise detection of biological targets and cellular processes. Recent advances in fluorescence imaging technologies now provide unprece...

A mean field theory for pulse-coupled neural oscillators based on the spike time response curve.

Journal of neurophysiology
A mean field method for pulse-coupled oscillators with delays used a self-connected oscillator to represent a synchronous cluster of - 1 oscillators and a single oscillator assumed to be perturbed from the cluster. A periodic train of biexponential ...

Eigenhearts: Cardiac diseases classification using eigenfaces approach.

Computers in biology and medicine
In the realm of cardiovascular medicine, medical imaging plays a crucial role in accurately classifying cardiac diseases and making precise diagnoses. However, the integration of data science techniques in this field presents significant challenges, ...