Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor response to pharmacological treatment, partially due to insufficient drug delivery across blood-brain barrier. In this study, we developed a novel ther...
Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
Subunit vaccines are crucial in preventing modern diseases due to their safety, stability, and ability to elicit targeted immune responses. However, challenges in antigen and adjuvant design hinder their development. Recent advancements in in-silico ...
Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
There is a lack of effective means for precise drug delivery of gastrointestinal diseases. Herein we report a novel magnetically controlled drug delivering capsule endoscope (MDCE) to achieve precision drug delivery for gastrointestinal diseases. MDC...
Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
Current immunotherapeutic approaches for autoimmune disorders primarily rely on the use of generalized immunosuppressive medications. However, most immune drugs and tolerogenic immunomodulators are insufficient on their own to establish antigen-speci...
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
May 9, 2025
Serial block-face scanning electron microscopy (SBF-SEM) is employed to achieve high-resolution volume reconstructions and detailed ultrastructural analyses of complex organelles. The performance of SBF-SEM is evaluated according to the accuracy of s...
International journal of molecular sciences
May 9, 2025
Currently, the focus of intraoperative imaging in brain tumor surgery is beginning to shift to optical methods such as optical coherence tomography (OCT), Raman spectroscopy, confocal laser endomicroscopy (CLE), and fluorescence lifetime imaging (FLI...
Scientific reports
May 9, 2025
Wildlife biologists increasingly use camera traps for monitoring animal populations. However, manually sifting through the collected images is expensive and time-consuming. Current deep learning studies for camera trap images do not adequately tackle...
Scientific reports
May 9, 2025
Animal sounds can be recognised automatically by machine learning, and this has an important role to play in biodiversity monitoring. Yet despite increasingly impressive capabilities, bioacoustic species classifiers still exhibit imbalanced performan...
Circulation research
May 9, 2025
Angiogenesis, the formation of new blood vessels, is a fundamental biological process with implications for both physiological functions and pathological conditions. While the transcriptional regulation of angiogenesis, mediated by factors such as HI...
Bioinspiration & biomimetics
May 9, 2025
In nature, organisms have evolved diverse grasping mechanisms to perform vital functions such as hunting and self-defence. These time-tested biological structures, including the arms of octopuses and the trunks of elephants, offer valuable inspiratio...