Clinica chimica acta; international journal of clinical chemistry
Jun 15, 2025
OBJECTIVES: The World Health Organization has identified Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) as significant public health threats owing to high antibiotic resistance. Traditional antibiotic susceptibility testing (AST) methods,...
Non-ribosomal peptides (NRPs) are promising lead compounds for novel antibiotics. Bioinformatic mining of silent microbial NRPS gene clusters provide crucial insights for the discovery and de novo design of bioactive peptides. Here, we describe the e...
The journal of physical chemistry letters
Jun 12, 2025
The growing prevalence of infectious diseases and the increasing threat of bacterial resistance have drawn widespread attention to antimicrobial inorganic nanomaterials. However, the diversity, abundance, and complex mechanisms of these materials pre...
Can we understand and predict the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology and in applied approaches to address the global health challenge of anti...
ACS biomaterials science & engineering
Jun 9, 2025
Bacterial infections have been demonstrated to cause the premature failure of implants. A reliable strategy for preserving biocompatibility is to physically modify the implant surface, without using chemicals, to prevent bacterial adhesion. This stud...
Journal of chemical information and modeling
Jun 9, 2025
(MAB) infections pose a significant treatment challenge due to their intrinsic resistance to antibiotics, requiring prolonged multidrug regimens with limited success and frequent relapses. tRNA (m1G37) methyltransferase (TrmD), an enzyme essential f...
BACKGROUND/AIM: Optimal antimicrobial selection for patients with febrile neutropenia (FN) may differ depending on the underlying mechanisms. We aimed to develop a model for predicting the severity of bacteremia in patients with FN and hematologic ma...
The Pediatric infectious disease journal
Jun 1, 2025
The development of artificial intelligence systems is revolutionizing many fields of medicine, but specific studies are still missing in pediatrics. In our study, we showed that an untrained free-to-use large language model provided reliable response...
Journal of infection in developing countries
May 31, 2025
INTRODUCTION: Antimicrobial resistance (AMR) is a global health challenge, and antimicrobial susceptibility testing (AST) is vital for guiding treatment. Although widely used, the Kirby-Bauer method depends on skilled interpretation, which can be tim...
This paper assesses the presentation of Gradient Boosting Regression (GBR), Ridge Regression (RR), and Particle Swarm Optimization (PSO) models in improving the photocatalytic destruction of antibiotic utilizing a UV/ZrO₂/NaOCl system. The GBR model ...
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