AIMC Topic: Antibodies, Bacterial

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The multiplexed single-tier InBios Lyme Detect Multiplex ELISA is more sensitive than standard two-tier tests in the early stages of Lyme disease.

Journal of clinical microbiology
UNLABELLED: There are nearly 500,000 cases of Lyme disease each year in the United States; 10%-20% of them result in the development of a debilitating chronic disease known as post-treatment Lyme disease. Existing standardized and modified two-tier t...

The potential to improve Lyme disease diagnostics through quantification of immunoglobulin class switching patterns.

Journal of clinical microbiology
N. Nair, A. Marques , E. J. Horn, G. Brown et al., J Clin Microbiol 63:e0034725, 2025, https://doi.org/10.1128/jcm.00347-25 present data to demonstrate that infection by , the primary causative agent of Lyme disease in the USA, leads to immunoglobuli...

Field-oriented assessment of bovine tuberculosis in Tunisian cattle: IDR, PCR and serological test prediction based on AI approaches.

World journal of microbiology & biotechnology
Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis), remains a major zoonotic and economically burdensome disease worldwide. In Tunisia, where bTB has remained present for many years, Efforts to eliminate the disease have been slowed ...

Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding.

Frontiers in immunology
INTRODUCTION: Lyme disease (LD) is a tick-borne disease that is a substantial public health burden with estimated about 0.5 million new cases per year in the US and increasing incidence. Differentiating Lyme disease, especially in its early stages, f...

Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence.

mBio
Vaccines to curb the global spread of multidrug-resistant gonorrhea are urgently needed. Here, 26 vaccine candidates identified by an artificial intelligence-driven platform (Efficacy Discriminative Educated Network[EDEN]) were screened for efficacy ...

Seroprevalence of antibodies for pertussis and diphtheria among people leaving or entering China: a cross-sectional study.

Journal of infection in developing countries
INTRODUCTION: Despite high population immunity, pertussis remains one of the leading causes of vaccine-preventable deaths worldwide. The aim of this study was to determine the seroprevalence of IgG antibodies to pertussis toxin (PT) and diphtheria am...

CbpM and CbpG of Streptococcus Pneumoniae Elicit a High Protection in Mice Challenged with a Serotype 19F Pneumococcus.

Iranian journal of allergy, asthma, and immunology
Among many pneumococcal antigens, choline-binding proteins (CPBs) display a high immunogenicity in animal models. This study aims to determine the immunogenicity of CbpM, CbpG and CbpL proteins of Streptococcus pneumoniae in a mice model. The genes w...

Haemophilus influenzae type b (Hib) seroprevalence and current epidemiology in England and Wales.

The Journal of infection
INTRODUCTION: The implementation of the Hib conjugate vaccine in the United Kingdom in 1992 resulted in a rapid decline in invasive Hib disease across all age groups. However, a resurgence in 2000-2002 prompted the introduction of additional control ...

Antigenic and pathogenicity activities of Ralstonia solanacearum race 3 biovar 2 molecularly identified and detected by indirect ELISA using polyclonal antibodies generated in rabbits.

Microbial pathogenesis
Eight molecular-characterized isolates of Ralstonia solanacearum from potato belonging to race 3 biovar 2, their virulence were evaluated on potato cv. Lady Rosette, tomato cv. Strain B, eggplant cv. Balady and pepper cv. Balady and showed high virul...