Influenza antiviral stockpiling represents a critical component of pandemic preparedness, yet evolving challenges demand new approaches to this strategic imperative. The Strategic National Stockpile's target of maintaining antiviral courses for 25% o...
Clinical pharmacology and therapeutics
Sep 1, 2025
In silico trials, utilizing mathematical models calibrated with clinical data, present a transformative approach to expedite drug development. We propose a virtual trial framework for chronic Hepatitis B, accurately simulating clinical protocols, pat...
The management of chronic hepatitis B (CHB) encounters challenges like suboptimal antiviral response and the lack of predictive biomarkers. In this study, the role of paternally expressed gene 10 (PEG10) in hepatitis B e antigen (HBeAg) seroconversio...
Viruses are transmitted through multiple routes and can cause a wide range of diseases. Antiviral peptides (AVPs) have emerged as a cost-effective and low-side-effect strategy for combating viral infections. However, identifying antiviral peptides ex...
Journal of chemical information and modeling
Jul 14, 2025
A critical assessment of computational hit-finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target. Twenty-three participating teams comprised of co...
European journal of medicinal chemistry
Jul 5, 2025
Bioactivity optimization is a crucial and technical task in the early stages of drug discovery, traditionally carried out through iterative substituent optimization, a process that is often both time-consuming and expensive. To address this challenge...
The COVID-19 pandemic has initiated a global health emergency, with an exigent need for an effective cure. Progressively, drug repurposing is emerging as a promising solution for saving time, cost, and labor. However, the number of drug candidates th...
Deforestation, urbanization, and climate change have significantly increased the risk of zoonotic diseases. Nipah virus (NiV) of Paramyxoviridae family and Henipavirus genus is transmitted by Pteropus bats. Climate-induced changes in bat migration pa...
The Nipah virus (NiV), a lethal pathogen from the Paramyxoviridae family, presents a significant global health threat as a result of its high mortality rate and inter-human transmission. This investigation employed in silico methods that were assiste...
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