Recent advancements in cardiac imaging have been significantly enhanced by integrating deep learning models, offering transformative potential in early diagnosis and patient care. The research paper explores the application of hybrid deep learning me...
Neural networks : the official journal of the International Neural Network Society
Dec 4, 2024
This article proposes a novel deep clustering model based on the variational autoencoder (VAE), named GamMM-VAE, which can learn latent representations of training data for clustering in an unsupervised manner. Most existing VAE-based deep clustering...
Periodontitis, a chronic inflammatory condition of the periodontium, is associated with over 60 systemic diseases. Despite advancements, precision medicine approaches have had limited success, emphasizing the need for deeper insights into cellular su...
Parkinson's disease (PD) is a neurodegenerative disorder that occurs as a result of a decrease in the chemical called dopamine in the brain. There is no definitive treatment for PD, but some medications used to control symptoms in the early stages ha...
OBJECTIVE: To identify blood-based biomarkers and therapeutic targets for Alzheimer's disease (AD) by leveraging single-cell RNA sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) and advanced deep learning techniques.
Studies in health technology and informatics
May 15, 2025
Patients admitted to the intensive care unit (ICU) are often treated with multiple high-risk medications. Over- and underprescribing of indicated medications, and inappropriate choice of medications frequently occur in the ICU. This risk has to be mi...
Reconstructing high-resolution gene regulatory networks (GRNs) based on single-cell RNA sequencing data provides an opportunity to gain insight into disease pathogenesis. At present, there are a large number of GRN reconstruction methods based on gra...
Single-cell multi-omics technologies have revolutionized the study of cell states and functions by simultaneously profiling multiple molecular layers within individual cells. However, existing methods for integrating these data struggle to preserve c...
With the rapid advances in single-cell sequencing technology, it is now feasible to conduct in-depth genetic analysis in individual cells. Study on the dynamics of single cells in response to perturbations is of great significance for understanding t...
Spatial transcriptomics (ST) technology provides gene expression profiles with spatial context, offering critical insights into cellular interactions and tissue architecture. A core task in ST is spatial domain identification, which involves detectin...
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