OBJECTIVE: Drug-drug interaction (DDI) is of serious concern, causing over 30% of all adverse drug reactions and resulting in significant morbidity and mortality. Early discovery of adverse DDI is critical to prevent patient harm. Spontaneous reporti...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Feb 10, 2017
The objective of the study is to assess the predictive performance of three different techniques as classifiers for extra-intestinal manifestations in 152 patients with Crohn's disease. Naïve Bayes, Bayesian Additive Regression Trees and Bayesian Net...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Feb 10, 2017
Abbreviation disambiguation in clinical texts is a problem handled well by fully supervised machine learning methods. Acquiring training data, however, is expensive and would be impractical for large numbers of abbreviations in specialized corpora. A...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Feb 10, 2017
Important information is encoded in free-text patient comments. We determine the most common topics in patient comments, design automatic topic classifiers, identify comments ' sentiment, and find new topics in negative comments. Our annotation schem...
Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our goal was to compare the performance of multiple linear regression (MLR) and eight machine learning techniques in pharmacogenetic algorithm-based prediction o...
Journal of computer-aided molecular design
Feb 2, 2017
Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain...
Computational intelligence and neuroscience
Jan 31, 2017
Inspired by the group decision making process, ensembles or combinations of classifiers have been found favorable in a wide variety of application domains. Some researchers propose to use the mixture of two different types of classification algorithm...
We present an integrated methodology for detecting, segmenting and classifying breast masses from mammograms with minimal user intervention. This is a long standing problem due to low signal-to-noise ratio in the visualisation of breast masses, combi...
There is a shortage of compounds that are directed towards new targets apart from those targeted by the FDA approved drugs used against Mycobacterium tuberculosis. Topoisomerase I (Mttopo I) is an essential mycobacterial enzyme and a promising target...
Journal of experimental psychology. General
Jan 12, 2017
Statistical learning is often considered to be a means of discovering the units of perception, such as words and objects, and representing them as explicit "chunks." However, entities are not undifferentiated wholes but often contain parts that contr...
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