AIMC Topic: Biological Products

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Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Nutrition research (New York, N.Y.) Nov 11, 2015
Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian...
Phellinus Ethnopharmacology Medicine, Korean Traditional Acetates Polysaccharides Neurons Polyphenols Nerve Tissue Proteins Fruiting Bodies, Fungal Gene Expression Regulation, Enzymologic Oxidoreductases Solvents MAP Kinase Signaling System Basidiomycota Antioxidants Plant Extracts Neuroprotective Agents Apoptosis Biological Products Republic of Korea Cell Line, Tumor Oxidative Stress Humans Brain
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A Liquid-Handling Robot for Automated Attachment of Biomolecules to Microbeads.

Journal of laboratory automation Aug 26, 2015
Diagnostics, drug delivery, and other biomedical industries rely on cross-linking ligands to microbead surfaces. Microbead functionalization requires multiple steps of liquid exchange, incubation, and mixing, which are laborious and time intensive. A...
Biological Products Robotics Microspheres
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Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes.

Bioprocess and biosystems engineering Jan 1, 2015
Currently, mammalian cells are the most utilized hosts for biopharmaceutical production. The culture media for these cell lines include commonly in their composition a pH indicator. Spectroscopic techniques are used for biopharmaceutical process moni...
Hydrogen-Ion Concentration Cricetinae Spectrophotometry, Ultraviolet Biological Products Cell Line Neural Networks, Computer Bioreactors Animals Culture Media
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Digital Butterworth filter as preprocessing method for implementing Raman spectroscopy as an analytical method in downstream processing of biopharmaceuticals.

Journal of chromatography. A Aug 16, 2025
For implementing Raman spectroscopy as an analytical method in downstream processing, extracting molecular information related to biopharmaceuticals is still challenging due to spectral variations caused by spectrometer, setup and fluorescence. This ...
Biological Products Linear Models Algorithms Spectrum Analysis, Raman
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Integrating network pharmacology and experimental validation to advance psoriasis treatment: Multi-target mechanistic elucidation of medicinal herbs and natural compounds.

Autoimmunity reviews Jul 31, 2025
BACKGROUND: Psoriasis, a chronic immune-mediated inflammatory disease (IMID), presents significant therapeutic challenges, necessitating exploration of alternative treatments like medicinal herbs (MH) and natural compounds (NC). Network pharmacology ...
Animals Signal Transduction Psoriasis Humans Network Pharmacology Biological Products Plants, Medicinal
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Predicting Biological Activity from Biosynthetic Gene Clusters Using Neural Networks.

Journal of chemical information and modeling Jul 14, 2025
Microorganisms such as bacteria and fungi have been used for natural products that translate to drugs. However, assessing the bioactivity of extract from culture to identify novel natural molecules remains a strenuous process due to the cumbersome or...
Neural Networks, Computer Machine Learning Bacteria Data Mining Multigene Family Biosynthetic Pathways Computational Biology Biological Products
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Target identification of natural products in cancer with chemical proteomics and artificial intelligence approaches.

Cancer biology & medicine Jul 9, 2025
Natural products (NPs) have long been recognized for their therapeutic potential, especially in cancer treatment, due to an ability to interact with multiple cellular pathways. The identification of molecular targets for NPs is a critical step in und...
Neoplasms Proteomics Biological Products Humans Artificial Intelligence Machine Learning
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Advances in pharmacotherapy of juvenile idiopathic arthritis.

Expert opinion on pharmacotherapy Jun 1, 2025
INTRODUCTION: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in childhood. More therapeutic options are available for the treatment of JIA with more children achieving minimal active disease or inactive disease statu...
Child Biological Products Arthritis, Juvenile Antirheumatic Agents Humans Biomarkers
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Computational screening of natural products as tryptophan 2,3-dioxygenase inhibitors: Insights from CNN-based QSAR, molecular docking, ADMET, and molecular dynamics simulations.

Computers in biology and medicine Jun 1, 2025
Parkinson's disease (PD) is characterised by a complex array of motor, psychiatric, and gastrointestinal symptoms, many of which are linked to disruptions in neuroactive metabolites. Dysregulated activity of tryptophan 2,3-dioxygenase (TDO), a key en...
Parkinson Disease Molecular Dynamics Simulation Enzyme Inhibitors Quantitative Structure-Activity Relationship Tryptophan Oxygenase Machine Learning Molecular Docking Simulation Biological Products Humans Neural Networks, Computer
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Molecular insights fast-tracked: AI in biosynthetic pathway research.

Natural product reports May 22, 2025
Covering: 2000 to 2025This review explores the potential of artificial intelligence (AI) in addressing challenges and accelerating molecular insights in biosynthetic pathway research, which is crucial for developing bioactive natural products with ap...
Deep Learning Biological Products Natural Language Processing Artificial Intelligence Machine Learning Data Mining Biosynthetic Pathways
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