AIMC Topic: Biological Products
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A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.
Scientific reports
Feb 28, 2018
AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines....
Specialized oxygenated heterocyclics from Villorita cyprinoides with cyclooxygenase-2 and 5-lipoxygenase inhibitory properties.
Food research international (Ottawa, Ont.)
Dec 28, 2017
Villorita cyprinoides is traditional seafood in the coastal regions of Arabian Sea. Bioactivity-guided purification of ethyl acetate:methanol extract of V. cyprinoides resulted in the identification of two O-spirocyclic ether derivatives (1-2) along ...
Characterization of Polyphenolic Content in the Aquatic Plants Ruppia cirrhosa and Ruppia maritima -A Source of Nutritional Natural Products.
Molecules (Basel, Switzerland)
Dec 22, 2017
Herein, the polyphenolic content in extracts of (Petagna) Grande and L.was fully characterized for the first time. High amounts of the main compound chicoric acid () (≤30.2 ± 4.3 mg/g) were found in both species. In addition, eight flavonoids, nam...
Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging.
Materials science & engineering. C, Materials for biological applications
Nov 28, 2017
Curcumin (Curc) reacts with zinc di‑iodine (ZnI) in 2:1molar ratio in the presence of an excess of a base triethylamine ((CHCH)N) in methanol (CHOH) solution towards the amorphous solid material of formula [ZnI(Curc)] (1). The complex was characteriz...
Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research.
Scientific reports
Oct 27, 2017
Various algorithms comparing 2D NMR spectra have been explored for their ability to dereplicate natural products as well as determine molecular structures. However, spectroscopic artefacts, solvent effects, and the interactive effect of functional gr...
The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis.
Journal of managed care & specialty pharmacy
Jul 17, 2017
BACKGROUND: Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA di...
Digital-to-biological converter for on-demand production of biologics.
Nature biotechnology
May 29, 2017
Manufacturing processes for biological molecules in the research laboratory have failed to keep pace with the rapid advances in automization and parellelization. We report the development of a digital-to-biological converter for fully automated, vers...
Computer-aided Dereplication and Structure Elucidation of Natural Products at the University of Reims.
Molecular informatics
Apr 27, 2017
Natural product chemistry began in Reims, France, in a pharmacognosy research laboratory whose main emphasis was the isolation and identification of bioactive molecules, following the guidelines of chemotaxonomy. The structure elucidation of new comp...
Simultaneous Determination of Five Active Components in the Chinese Patent Medicine Niuhuang Jiangya Pill by HPLC-MS/MS.
Journal of AOAC International
Dec 16, 2016
Niuhuang Jiangya (NHJY) pill is one of the well-known Chinese patent medicines in China used in the treatment of high blood pressure. The primary purpose of this study was to establish and validate a method using HPLC with tandem MS for the quality e...
Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.
International journal of clinical and experimental pathology
Dec 1, 2015
Interleukin-33 (IL-33) is a cytokine that belongs to the interleukin-1 family and has been shown to be associated with mucosal inflammation. The aim of this study was to determine the serum level of IL-33 in children with ulcerative colitis (UC) and ...
Adolescent
Child
Enzyme-Linked Immunosorbent Assay
Age Factors
Male
Severity of Illness Index
Case-Control Studies
Saudi Arabia
C-Reactive Protein
Crohn Disease
Inflammation Mediators
Up-Regulation
Biological Products
Colitis, Ulcerative
Diagnosis, Differential
Predictive Value of Tests
Humans
Prospective Studies
Biomarkers
Prognosis
Female
Cross-Sectional Studies
Nephelometry and Turbidimetry
Interleukin-33
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