Many genome-wide studies capture isolated moments in cell differentiation or organismal development. Conversely, longitudinal studies provide a more direct way to study these kinetic processes. Here, we present an approach for modeling gene-expressio...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 15, 2025
Diabetic encephalopathy is a progressive complication of type 2 diabetes, yet its region-specific biochemical changes remain unclear. In this study, we applied Fourier Transform Infrared Microspectroscopy (FTIRM) to assess metabolic alterations in th...
Time flows in one direction, a physical constraint humans recognize, as reflected in proverbs such as "there is no crying over spilt milk." Recent work from our laboratory has demonstrated that human participants rely on specific cues to discriminate...
Alzheimer's disease (AD) diagnosis hinges on detecting amyloid beta (Aβ) plaques and neurofibrillary tau (τ) tangles, typically assessed using PET imaging. While accurate, these modalities are expensive and not widely accessible, limiting their utili...
Alzheimer's disease is a progressive neurodegenerative disorder marked by cognitive decline, memory loss, and behavioral changes. Early diagnosis, particularly identifying Early Mild Cognitive Impairment (EMCI), is vital for managing the disease and ...
Cognitive aging, a pivotal domain at the intersection of neuroscience and psychology, exhibits a strong association with neurodegenerative disorders; however, its comprehensive underlying mechanisms remain incompletely elucidated. This review aims to...
Brain stroke is an illness which affects almost every age group, particularly people over 65. There are two significant kinds of strokes: ischemic and hemorrhagic strokes. Blockage of brain vessels causes an ischemic stroke, while cracks in blood ves...
BACKGROUND: Alzheimer's disease (AD) is the principal cause of dementia and requires the early diagnosis of people with mild cognitive impairment (MCI) who are at high risk of progressing. Early diagnosis is imperative for optimizing clinical managem...
Brain insulin action plays an important role in metabolic and cognitive health, but there is no biomarker available to assess brain insulin resistance in humans. Here, we developed a machine learning framework based on blood DNA methylation profiles ...
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