AIMC Topic: Carcinoma, Pancreatic Ductal

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Explainable machine learning identifies a polygenic risk score as a key predictor of pancreatic cancer risk in the UK Biobank.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
BACKGROUND: Predicting the risk of developing pancreatic ductal adenocarcinoma (PDAC) is of paramount importance, given its high mortality rate. Current PDAC risk prediction models rely on a limited number of variables, do not include genetics, and h...

Computed tomography-based fully automated artificial intelligence model to predict extrapancreatic perineural invasion in pancreatic ductal adenocarcinoma.

International journal of surgery (London, England)
BACKGROUND: Extrapancreatic perineural invasion (EPNI) increases the risk of postoperative recurrence in pancreatic ductal adenocarcinoma (PDAC). This study aimed to develop and validate a computed tomography (CT)-based, fully automated preoperative ...

Deep Learning and Automatic Differentiation of Pancreatic Lesions in Endoscopic Ultrasound: A Transatlantic Study.

Clinical and translational gastroenterology
INTRODUCTION: Endoscopic ultrasound (EUS) allows for characterization and biopsy of pancreatic lesions. Pancreatic cystic neoplasms (PCN) include mucinous (M-PCN) and nonmucinous lesions (NM-PCN). Pancreatic ductal adenocarcinoma (P-DAC) is the commo...

Diagnosis of Pancreatic Ductal Adenocarcinoma Using Deep Learning.

Sensors (Basel, Switzerland)
Recent advances in artificial intelligence (AI) research, particularly in image processing technologies, have shown promising applications across various domains, including health care. There is a significant effort to use AI for the early diagnosis ...

Construction of a combined prognostic model for pancreatic ductal adenocarcinoma based on deep learning and digital pathology images.

BMC gastroenterology
BACKGROUND: Deep learning has made significant advancements in the field of digital pathology, and the integration of multiple models has further improved accuracy. In this study, we aimed to construct a combined prognostic model using deep learning-...

Advancements in early detection of pancreatic cancer: the role of artificial intelligence and novel imaging techniques.

Abdominal radiology (New York)
Early detection is crucial for improving survival rates of pancreatic ductal adenocarcinoma (PDA), yet current diagnostic methods can often fail at this stage. Recently, there has been significant interest in improving risk stratification and develop...

Key genes and pathways in the molecular landscape of pancreatic ductal adenocarcinoma: A bioinformatics and machine learning study.

Computational biology and chemistry
Pancreatic ductal adenocarcinoma (PDAC) is recognized for its aggressive nature, dismal prognosis, and a notably low five-year survival rate, underscoring the critical need for early detection methods and more effective therapeutic approaches. This r...

A convolutional neural network-based system for identifying neuroendocrine neoplasms and multiple types of lesions in the pancreas using EUS (with videos).

Gastrointestinal endoscopy
BACKGROUND AND AIMS: EUS is sensitive in detecting pancreatic neuroendocrine neoplasm (pNEN). However, the endoscopic diagnosis of pNEN is operator-dependent and time-consuming because pNEN mimics normal pancreas and other pancreatic lesions. We inte...

A time-dependent explainable radiomic analysis from the multi-omic cohort of CPTAC-Pancreatic Ductal Adenocarcinoma.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: In Pancreatic Ductal Adenocarcinoma (PDA), multi-omic models are emerging to answer unmet clinical needs to derive novel quantitative prognostic factors. We realized a pipeline that relies on survival machine-learning (SML) ...