AIMC Topic: Chitosan

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Chitosan/nanohydroxyapatite composite based scallop shells as an efficient adsorbent for mercuric ions: Static and dynamic adsorption studies.

International journal of biological macromolecules
Chitosan/nanohydroxyapatite composites based on scallop shells (CP12, CP14 and CP21) were prepared with different chitosan: nanohydroxyapatite ratios (1:2, 1:4 and 2:1, respectively). Nanohydroxyapatite (P), chitosan(C) and their composites were char...

Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property.

Carbohydrate polymers
In this paper, novel cationic chitosan derivative possessing 1,2,3-triazolium and pyridinium groups was synthesized conveniently via cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) and methylation. FTIR, H NMR, and elemental analysis examined th...

Synthesis, characterization and antifungal efficacy of C-coordinated O-carboxymethyl chitosan Cu(II) complexes.

Carbohydrate polymers
A novel type of O-carboxymethyl chitosan Schiff bases (O-CSPX) was synthesized via a condensation reaction. After the coordination reaction of cupric ions, Cu(II) complexes (O-CSPX-Cu) were achieved. The theoretical structure of O-CSPX-Cu calculated ...

Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks.

International journal of biological macromolecules
At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium tripolyphosphate (TPP) concentrations and mass ratios were optimized to improve the process yield without undesirable particle flocculation. Prepared formulations ...

Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.

Journal of pharmaceutical sciences
Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology requires the development of formulations with higher concentrations to reach therapeutic dosages. Polyplexe...

Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells.

Materials science & engineering. C, Materials for biological applications
Metallic nanoparticles often attribute severe adverse effects to the various organs or tissues at the molecular level despite of their applications in medical, laboratory and industrial sectors. The present study highlights the preparation of copper ...

Cytotoxicity of chitosan/streptokinase nanoparticles as a function of size: An artificial neural networks study.

Nanomedicine : nanotechnology, biology, and medicine
Predicting the size and toxicity of chitosan/streptokinase nanoparticles at various values of processing parameters was the aim of this study. For the first time, a comprehensive model could be developed to determine the cytotoxicity of the nanoparti...

Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives.

Bioorganic & medicinal chemistry letters
Three novel 6-N-substituted chitosan derivatives were designed and synthesised and characterized by FTIR and NMR. The degree of substitution was calculated by elemental analysis results. The antimicrobial activities of the target compounds were evalu...

Artificial neural network-based fungal chitin production for submicron-chitosan synthesis: effects on bioremediation for heavy metal pollution.

International journal of biological macromolecules
This study focused on optimizing fungal chitin (CT) production from a newly identified Fusarium incarnatum (GenBank: OL314753) for subsequent synthesis of submicron chitosan (sm-CS) tailored for enhanced heavy metal removal. Initial attempts to optim...

Chitosan-based adsorbents for remediation of toxic dyes from wastewater: A review on adsorption mechanism, reusability, machine learning based modeling and future perspectives.

International journal of biological macromolecules
The disposal of recalcitrant dyes in aquatic environments from various industrial sectors is a threat to both the plant and animal kingdom. The presence of dyes in various water bodies undermines the availability of uncontaminated drinking water and ...