Tyrosinase plays a central role in melanin biosynthesis, and its dysregulation has been implicated in the pathogenesis of various pigmentation disorders. The precise identification of tyrosinase inhibitory peptides (TIPs) is critical, as these bioact...
Nitrogen-vacancy (NV) centers in diamond demonstrate advantages in biosensing due to their exceptional photostability and long spin coherence time. However, clinical applications of NV centers are significantly limited because their spin states lack ...
Artificial intelligence (AI) molecular generation is a highly promising strategy in the drug discovery, with deep reinforcement learning (RL) models emerging as powerful tools. This study introduces a fragment-by-fragment growth RL forward molecular...
Tyrosinase is pivotal for melanin formation. Measuring monophenolase activity is of great importance for both fundamental research and industrial applications. For the first time, a backpropagation (BP) artificial neural network with three-dimensiona...
Developing new, cheap, sensitive and selective chemiluminescence (CL) systems with multiple detection properties is still a big challenge for biological and environmental applications. Here, we report a new CL system having multiple detection applica...
SAR and QSAR in environmental research
Feb 1, 2021
Tyrosinase is a key rate-limiting enzyme in the process of melanin synthesis, which is closely related to human pigmentation disorders. Tyrosinase inhibitors can down-regulate tyrosinase to effectively reduce melanin synthesis. In this work, we condu...
Organophosphorus pesticide (OP) residues in agricultural products, herbal medicines and environment have attracted increasing concerns because they cause high healthy risk. Herein, a tyrosinase-mediated photoinduced electron transfer system was const...
This study presents the chemical profile investigation of a 70% ethanol extract obtained from Scabiosa stellata, a medicinal herbaceous traditionally used to treat heel cracks. A C NMR-based dereplication methodology was firstly applied on centrifuga...
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
Medicinal plants are long been used for pharmaceutical and cosmetic industry. Among medicinal plants, Polygonum amplexicaule of family polygonaceae has traditional use in medicines and skin care. P. amplexicaule belongs to genus Polygonum that contai...
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