AIMC Topic: Chromatography, High Pressure Liquid

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THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.

Acta poloniae pharmaceutica May 1, 2017
Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy c...
Male Middle Aged Kidney Infusions, Intravenous Female Aged Aged, 80 and over Adult Chromatography, High Pressure Liquid Biological Availability Half-Life Kidney Neoplasms Metabolic Clearance Rate Area Under Curve Drug Monitoring Models, Biological Antipyretics Humans Renal Elimination Spectrophotometry, Ultraviolet Acetaminophen Analgesics, Non-Narcotic Nephrectomy
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HPLC METHOD FOR SEPARATING ENANTIOMERS OF IMIDAZOLE DERIVATIVES - ANTIFUNGAL COMPOUNDS.

Acta poloniae pharmaceutica May 1, 2017
The aim of this study was to test separation possibility of enantiomers of nine active substances belonging to imidazole derivatives: bifonazole, butoconazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sertaconazole and tiocona...
Chromatography, High Pressure Liquid Solvents Buffers Imidazoles Antifungal Agents Hydrogen-Ion Concentration
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Caspofungin infusion solutions (50 mg/100 mL): chemical stability and antifungal activity against Candida spp.

Die Pharmazie Apr 1, 2017
BACKGROUND: Ready to use caspofungin infusion bags are centrally prepared in the Hospital Pharmacy, University Hospital of Heidelberg, for economic reasons and possibly occurring problems with drug shortages. The aim of this study was a quality contr...
Microbial Sensitivity Tests Time Factors Candida Antifungal Agents Pharmaceutical Solutions Lipopeptides Caspofungin Echinocandins Infusions, Parenteral Chromatography, High Pressure Liquid Drug Stability Drug Storage Sodium Chloride
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PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta poloniae pharmaceutica Mar 1, 2017
Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood s...
Chromatography, High Pressure Liquid Healthy Volunteers Humans Area Under Curve Pakistan Young Adult Half-Life Models, Biological Administration, Oral Male Metabolic Clearance Rate Sulfonamides Cross-Over Studies Anti-Inflammatory Agents, Non-Steroidal Therapeutic Equivalency Tablets
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DEVELOPMENT AND VALIDATION OF FAST REVERSED-PHASE HPLC METHOD FOR ANALYSIS OF ESOMEPRAZOLE IN RABBIT PLASMA.

Acta poloniae pharmaceutica Mar 1, 2017
The present study focused to develop rapid, accurate and sensitive reversed-phase high pressure liquid chromatography method for the quantification of esomeprazole (ESO) magnesium in rabbit plasma. Chromatographic separation was achieved isocraticall...
Proton Pump Inhibitors Methanol Esomeprazole Rabbits Potassium Compounds Reproducibility of Results Buffers Spectrophotometry, Ultraviolet Hydrogen-Ion Concentration Animals Chromatography, Reverse-Phase Chromatography, High Pressure Liquid Limit of Detection Acetonitriles Cold Temperature Drug Monitoring Solvents Freezing Drug Stability Hydroxides Linear Models
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REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF 5-FLUOROURACIL IN RABBIT PLASMA.

Acta poloniae pharmaceutica Mar 1, 2017
A simple, efficient, accurate and selective HPLC method has been developed and validated successfully for the estimation of 5-fluorouracil in rabbit plasma. The drug was eluted by using Supelco C18 column (1.5 cm x 4.6 mm, 5 μm) with a mobile phase c...
Drug Monitoring Methanol Rabbits Hydrogen-Ion Concentration Solvents Linear Models Buffers Fluorouracil Chromatography, High Pressure Liquid Reproducibility of Results Perchlorates Animals Chromatography, Reverse-Phase Water Calibration Limit of Detection Reference Standards Antimetabolites, Antineoplastic
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DEVELOPMENT AND VALIDATION OF HPLC ANALYTICAL METHODS USED-FOR DETERMINATION OF ASSAY, CONTENT UNIFORMITY AND DISSOLUTION OF IMMEDIATE RELEASE CANDESARTAN CILEXETIL 32 MG TABLETS.

Acta poloniae pharmaceutica Mar 1, 2017
New analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies wer...
Angiotensin II Type 1 Receptor Blockers Buffers Chemistry, Pharmaceutical Tetrazoles Hydrogen-Ion Concentration Temperature Solvents Benzimidazoles Tablets Reproducibility of Results Drug Compounding Drug Liberation Chromatography, High Pressure Liquid Limit of Detection Linear Models Biphenyl Compounds Solubility
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Comparative study between UHPLC-UV and UPLC-MS/MS methods for determination of alogliptin and metformin in their pharmaceutical combination.

Die Pharmazie Feb 1, 2017
A new UPLC-MS/MS method (method A), for simultaneous determination of alogliptin (ALN) and metformin (MET) in their recently approved pharmaceutical combination Kazano® tablets, was developed and compared to a new UHPLC-UV method (method B). Concerni...
Tablets Chromatography, High Pressure Liquid Tandem Mass Spectrometry Spectrometry, Mass, Electrospray Ionization Metformin Piperidines Uracil Sensitivity and Specificity Hypoglycemic Agents Drug Combinations
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STABILITY INDICATIVE HPLC DETERMINATION OF RELATED SUBSTANCES AND IDENTIFICATION OF POTENTIAL DEGRADANTS USING LC-MS IN TRIPLE COMBINATION ANTIRETROVIRAL TABLETS.

Acta poloniae pharmaceutica Jan 1, 2017
A rapid stability indicating liquid chromatography method was developed and validated for the simultaneous quantitation of related substances of antiretrovirals in combined oral dosage formulation. Separation was achieved using a Waters, Xterra RP-18...
Drug Combinations Chromatography, High Pressure Liquid Tablets Tandem Mass Spectrometry Anti-Retroviral Agents Drug Stability
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STABILITY-INDICATING HPLC METHOD FOR DETERMINATION OF VANCOMYCIN HYDROCHLORIDE IN THE PHARMACEUTICAL DOSAGE FORMS.

Acta poloniae pharmaceutica Jan 1, 2017
A simple, rapid and selective RP-HPLC method was developed for the determination of vancomycin hydrochloride. The separation was achieved using a Capital C8-Optimal column (250 x 4.6 mm i.d., 5 μm particle size) with a mobile phase composed of buffer...
Chromatography, High Pressure Liquid Drug Stability Vancomycin Chromatography, Reverse-Phase
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