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Clinical Trials as Topic

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Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension.

The Lancet. Digital health
The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed. This guidance has been instrumental in promoting transparent eva...

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension.

The Lancet. Digital health
The CONSORT 2010 statement provides minimum guidelines for reporting randomised trials. Its widespread use has been instrumental in ensuring transparency in the evaluation of new interventions. More recently, there has been a growing recognition that...

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI Extension.

BMJ (Clinical research ed.)
The CONSORT 2010 (Consolidated Standards of Reporting Trials) statement provides minimum guidelines for reporting randomised trials. Its widespread use has been instrumental in ensuring transparency when evaluating new interventions. More recently, t...

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI Extension.

BMJ (Clinical research ed.)
The SPIRIT 2013 (The Standard Protocol Items: Recommendations for Interventional Trials) statement aims to improve the completeness of clinical trial protocol reporting, by providing evidence-based recommendations for the minimum set of items to be a...

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension.

Nature medicine
The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol reporting by providing evidence-based recommendations for the minimum set of items to be addressed. This guidance has been instrumental in promoting transparent eva...

Functional cardiac CT-Going beyond Anatomical Evaluation of Coronary Artery Disease with Cine CT, CT-FFR, CT Perfusion and Machine Learning.

The British journal of radiology
The aim of this review is to provide an overview of different functional cardiac CT techniques which can be used to supplement assessment of the coronary arteries to establish the significance of coronary artery stenoses. We focus on cine-CT, CT-FFR,...

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes.

PloS one
In clinical trials, animal and cell line models are often used to evaluate the potential toxic effects of a novel compound or candidate drug before progressing to human trials. However, relating the results of animal and in vitro model exposures to r...