International journal of neural systems
Jul 22, 2016
Computer-aided diagnosis (CAD) systems constitute a powerful tool for early diagnosis of Alzheimer's disease (AD), but limitations on interpretability and performance exist. In this work, a fully automatic CAD system based on supervised learning meth...
Brain network alterations in patients with Alzheimer's disease (AD) has been the subject of much investigation, but the biological mechanisms underlying these alterations remain poorly understood. Here, we aim to identify the changes in brain network...
Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer's disease (AD). Non-invasive diagnostic methods are desirable to identify MCI for early therapeutic interventions. In this study, we proposed a support...
IEEE transactions on bio-medical engineering
Apr 13, 2016
Sparse learning has been widely investigated for analysis of brain images to assist the diagnosis of Alzheimer's disease and its prodromal stage, i.e., mild cognitive impairment. However, most existing sparse learning-based studies only adopt cross-s...
International journal of neural systems
Apr 4, 2016
Computer Aided Diagnosis (CAD) constitutes an important tool for the early diagnosis of Alzheimer's Disease (AD), which, in turn, allows the application of treatments that can be simpler and more likely to be effective. This paper explores the constr...
Studies on resting-state functional Magnetic Resonance Imaging (rs-fMRI) have shown that different brain regions still actively interact with each other while a subject is at rest, and such functional interaction is not stationary but changes over ti...
As shown in the literature, methods based on multiple templates usually achieve better performance, compared with those using only a single template for processing medical images. However, most existing multi-template based methods simply average or ...
Cerebrospinal fluid (CSF) concentrations of YKL-40 that serve as biomarker of neuroinflammation are known to be altered along the clinico-biological continuum of Alzheimer's disease (AD). The specific structural cerebral correlates of CSF YKL-40 were...
Accurate diagnosis of Alzheimer's disease and its prodromal stage, i.e., mild cognitive impairment, is very important for early treatment. Over the last decade, various machine learning methods have been proposed to predict disease status and clinica...
Journal of the American Medical Directors Association
Jun 18, 2015
OBJECTIVES: To examine effects on symptoms of agitation and depression in nursing home residents with moderate to severe dementia participating in a robot-assisted group activity with the robot seal Paro.
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