AI Medical Compendium Topic

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A fuzzy robust optimization model for dual objective forward and reverse logistics networks considering carbon emissions.

PloS one
The inherent unpredictability within the low-carbon integrated supply chain logistics network complicates its management. This paper endeavours to address the challenge of designing a low-carbon logistics network within a context of uncertainty and w...

Mediation CNN (Med-CNN) Model for High-Dimensional Mediation Data.

International journal of molecular sciences
Complex biological features such as the human microbiome and gene expressions play a crucial role in human health by mediating various biomedical processes that influence disease progression, such as immune responses and metabolic processes. Understa...

A novel seven-tier framework for the classification of MEFV missense variants using adaptive and rigid classifiers.

Scientific reports
There is a great discrepancy between the clinical categorization of MEFV gene variants and in silico tool predictions. In this study, we developed a seven-tier classification system for MEFV missense variants of unknown significance and recommended a...

Employing Automated Machine Learning (AutoML) Methods to Facilitate the ADMET Properties Prediction.

Journal of chemical information and modeling
The rationale for using ADMET prediction tools in the early drug discovery paradigm is to guide the design of new compounds with favorable ADMET properties and ultimately minimize the attrition rates of drug failures. Artificial intelligence (AI) in ...

Understanding the Spatio-Temporal Coupling of Spikes and Spindles in Focal Epilepsy Through a Network-Level Computational Model.

International journal of neural systems
The electrophysiological findings have shown that epileptiform spikes triggering sleep spindles within 1[Formula: see text]s across multiple channels are commonly observed during sleep in focal epilepsy (FE). Such spatio-temporal couplings of spikes ...

Stable heteroclinic channels as a decision-making model: overcoming low signal-to-noise ratio with mutual inhibition.

Bioinspiration & biomimetics
Bio-inspired robot controllers are becoming more complex as we strive to make them more robust to, and flexible in, noisy, real-world environments. A stable heteroclinic network (SHN) is a dynamical system that produces cyclical state transitions usi...

Control of medical digital twins with artificial neural networks.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
The objective of precision medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be personalized and dyn...

Exponential stability of infinite-dimensional impulsive stochastic systems with Poisson jumps under aperiodically intermittent control.

Neural networks : the official journal of the International Neural Network Society
This paper studies the problem of mean square exponential stability (ES) for a class of impulsive stochastic infinite-dimensional systems with Poisson jumps (ISIDSP) using aperiodically intermittent control (AIC). It provides a detailed analysis of i...

Development of hybrid robust model based on computational modeling and machine learning for analysis of drug sorption onto porous adsorbents.

Scientific reports
This study investigates the utilization of three regression models, i.e., Kernel Ridge Regression (KRR), nu-Support Vector Regression ([Formula: see text]-SVR), and Polynomial Regression (PR) for the purpose of forecasting the concentration (C) of a ...

Reinforcement learning for automated method development in liquid chromatography: insights in the reward scheme and experimental budget selection.

Journal of chromatography. A
Chromatographic problem solving, commonly referred to as method development (MD), is hugely complex, given the many operational parameters that must be optimized and their large effect on the elution times of individual sample compounds. Recently, th...