Understanding microbial dynamics in natural environments remains a significant challenge. As an alternative approach, studying model bacterial strains under well-defined laboratory conditions can reveal ecological niche patterns and evolutionary cons...
This research investigates the impact of bacterial growth on the pH of culture media, emphasizing its significance in microbiological and biotechnological applications. A range of sophisticated artificial intelligence methods, including One-Dimension...
Cell culture technologies are widely used in academia and industry, yet optimizing culture media remains an art due to the complexity of cell-medium interactions. Machine learning has emerged as a promising solution, but it is hindered by biological ...
Degenerative joint diseases are major contributors to pain, impaired mobility, and an increasing socioeconomic burden in aging populations. Tissue Engineering (TE) offers alternative solutions to restore joint functions. However, current TE approache...
This study has demonstrated the optimization of the defined medium that significantly enhanced the production of recombinant monoclonal antibody (mAb) Tocilizumab (TCZ) as full-length and Fab fragment from Pichia pastoris. Out of the four tested defi...
Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the tit...
Maintaining consistent quality in biomanufacturing is essential for producing high-quality complex biologics. Yet, current process analytical technologies (PAT) often fall short in achieving rapid and accurate monitoring of small-molecule critical pr...
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Mar 26, 2025
The viability of cell-based medicinal products (CBMPs) is a critical quality attribute and must be assessed throughout the product lifecycle to contribute to a safe and potent drug product. In this study, we investigated the impact of short-term liqu...
The development of optimized culture media is pivotal to advancements in human cell culture, underpinning progress in regenerative medicine, cell therapies, and personalized medicine. While foundational formulations like Eagle's Minimum Essential Med...
Frontiers in cellular and infection microbiology
Jan 6, 2025
BACKGROUND: The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of ...
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