Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
Epistasis detection is a hot topic in bioinformatics due to its relevance to the detection of specific phenotypic traits and gene-gene interactions. Here, we present a step-by-step protocol to apply Epi-GTBN, a machine learning-based method based on ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
In biology, the term "epistasis" indicates the effect of the interaction of a gene with another gene. A gene can interact with an independently sorted gene, located far away on the chromosome or on an entirely different chromosome, and this interacti...
Journal of cardiovascular medicine (Hagerstown, Md.)
Jan 1, 2021
AIMS: Approximately 50% of patients with heart failure have preserved (≥50%) ejection fraction (HFpEF). Improved understanding of the phenotypic heterogeneity of HFpEF might facilitate development of targeted therapies and interventions.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
Using different sources of information to support automated extracting of relations between biomedical concepts contributes to the development of our understanding of biological systems. The primary comprehensive source of these relations is biomedic...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
With the biomedical field generating large quantities of time series data, there has been a growing interest in developing and refining machine learning methods that allow its mining and exploitation. Classification is one of the most important and c...
Journal of the American Medical Informatics Association : JAMIA
Dec 9, 2020
OBJECTIVE: The goal of this study is to explore transformer-based models (eg, Bidirectional Encoder Representations from Transformers [BERT]) for clinical concept extraction and develop an open-source package with pretrained clinical models to facili...
Journal of the American Medical Informatics Association : JAMIA
Dec 9, 2020
OBJECTIVE: In applying machine learning (ML) to electronic health record (EHR) data, many decisions must be made before any ML is applied; such preprocessing requires substantial effort and can be labor-intensive. As the role of ML in health care gro...
Natural language processing (NLP) is widely applied in biological domains to retrieve information from publications. Systems to address numerous applications exist, such as biomedical named entity recognition (BNER), named entity normalization (NEN) ...
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