AIMC Topic:
Data Mining

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Epistasis Detection Based on Epi-GTBN.

Methods in molecular biology (Clifton, N.J.)
Epistasis detection is a hot topic in bioinformatics due to its relevance to the detection of specific phenotypic traits and gene-gene interactions. Here, we present a step-by-step protocol to apply Epi-GTBN, a machine learning-based method based on ...

Brief Survey on Machine Learning in Epistasis.

Methods in molecular biology (Clifton, N.J.)
In biology, the term "epistasis" indicates the effect of the interaction of a gene with another gene. A gene can interact with an independently sorted gene, located far away on the chromosome or on an entirely different chromosome, and this interacti...

Phenotypic clustering of heart failure with preserved ejection fraction reveals different rates of hospitalization.

Journal of cardiovascular medicine (Hagerstown, Md.)
AIMS: Approximately 50% of patients with heart failure have preserved (≥50%) ejection fraction (HFpEF). Improved understanding of the phenotypic heterogeneity of HFpEF might facilitate development of targeted therapies and interventions.

Using Neural Networks for Relation Extraction from Biomedical Literature.

Methods in molecular biology (Clifton, N.J.)
Using different sources of information to support automated extracting of relations between biomedical concepts contributes to the development of our understanding of biological systems. The primary comprehensive source of these relations is biomedic...

Machine Learning for Biomedical Time Series Classification: From Shapelets to Deep Learning.

Methods in molecular biology (Clifton, N.J.)
With the biomedical field generating large quantities of time series data, there has been a growing interest in developing and refining machine learning methods that allow its mining and exploitation. Classification is one of the most important and c...

Clinical concept extraction using transformers.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: The goal of this study is to explore transformer-based models (eg, Bidirectional Encoder Representations from Transformers [BERT]) for clinical concept extraction and develop an open-source package with pretrained clinical models to facili...

Democratizing EHR analyses with FIDDLE: a flexible data-driven preprocessing pipeline for structured clinical data.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: In applying machine learning (ML) to electronic health record (EHR) data, many decisions must be made before any ML is applied; such preprocessing requires substantial effort and can be labor-intensive. As the role of ML in health care gro...

Biomedical named entity recognition and linking datasets: survey and our recent development.

Briefings in bioinformatics
Natural language processing (NLP) is widely applied in biological domains to retrieve information from publications. Systems to address numerous applications exist, such as biomedical named entity recognition (BNER), named entity normalization (NEN) ...