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Interpretable machine learning unveils key predictors and default values in an expanded database of human in vitro dermal absorption studies with pesticides.

Regulatory toxicology and pharmacology : RTP
The skin is the main route of exposure to plant protection products for operators, workers, residents, and bystanders. Assessing dermal absorption is key for evaluating pesticide exposure. The initial approach to risk assessment involves using defaul...

Enhancing Blood-Brain Barrier Penetration Prediction by Machine Learning-Based Integration of Novel and Existing, In Silico and Experimental Molecular Parameters from a Standardized Database.

Journal of chemical information and modeling
Predicting blood-brain barrier (BBB) penetration is crucial for developing central nervous system (CNS) drugs, representing a significant hurdle in successful clinical phase I studies. One of the most valuable properties for this prediction is the po...

Using Machine Learning to Predict Outcomes Following Thoracic and Complex Endovascular Aortic Aneurysm Repair.

Journal of the American Heart Association
BACKGROUND: Thoracic endovascular aortic repair (TEVAR) and complex endovascular aneurysm repair (EVAR) are complex procedures that carry a significant risk of complications. While risk prediction tools can aid in clinical decision making, they remai...

MLFusion: Multilevel Data Fusion using CNNs for atrial fibrillation detection.

Computers in biology and medicine
Data fusion, involving the simultaneous integration of signals from multiple sensors, is an emerging field that facilitates more accurate inferences in instrumentation applications. This paper presents a novel fusion methodology for multi-sensor mult...

A Generative Shape Compositional Framework to Synthesize Populations of Virtual Chimeras.

IEEE transactions on neural networks and learning systems
Generating virtual organ populations that capture sufficient variability while remaining plausible is essential to conduct in silico trials (ISTs) of medical devices. However, not all anatomical shapes of interest are always available for each indivi...

Clinical Application of Artificial Intelligence Preoperative Planning System Combined with Expert Database Retrieval in Complex Revision Hip Surgery.

Journal of visualized experiments : JoVE
Accurate preoperative planning in revision hip arthroplasty is crucial for achieving successful outcomes. To enhance the intuitive evaluation of acetabular bone defect severity and leverage previous successful experience in revision hip arthroplasty,...

Enhancing atrial fibrillation detection in PPG analysis with sparse labels through contrastive learning.

Computer methods and programs in biomedicine
BACKGROUND: With the advancements in wearable technology, photoplethysmography (PPG) has emerged as a promising technique for detecting atrial fibrillation (AF) due to its ability to capture cardiovascular information. However, current deep learning-...

Enhancing biomedical named entity recognition with parallel boundary detection and category classification.

BMC bioinformatics
BACKGROUND: Named entity recognition is a fundamental task in natural language processing. Recognizing entities in biomedical text, known as the BioNER, is particularly crucial for cutting-edge applications. However, BioNER poses greater challenges c...