AIMC Topic: Disease Models, Animal

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Embryonic cranial cartilage defects in the Fgfr3 mouse model of achondroplasia.

Anatomical record (Hoboken, N.J. : 2007) Sep 25, 2023
Achondroplasia, the most common chondrodysplasia in humans, is caused by one of two gain of function mutations localized in the transmembrane domain of fibroblast growth factor receptor 3 (FGFR3) leading to constitutive activation of FGFR3 and subseq...
Animals Mice Disease Models, Animal Skull X-Ray Microtomography Achondroplasia Receptor, Fibroblast Growth Factor, Type 3 Mutation Cartilage
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Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using deep-learning-based semantic segmentation in histology.

Biology open Sep 21, 2023
This study focuses on ischaemia-reperfusion injury (IRI) in kidneys, a cause of acute kidney injury (AKI) and end-stage kidney disease (ESKD). Traditional kidney damage assessment methods are semi-quantitative and subjective. This study aims to use a...
Acute Kidney Injury Animals Reperfusion Injury Deep Learning Semantics Mice Necrosis Disease Models, Animal
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Combining electromyographic and electrical impedance data sets through machine learning: A study in D2-mdx and wild-type mice.

Muscle & nerve Sep 2, 2023
INTRODUCTION/AIMS: Needle impedance-electromyography (iEMG) assesses the active and passive electrical properties of muscles concurrently by using a novel needle with six electrodes, two for EMG and four for electrical impedance myography (EIM). Here...
Animals Male Mice Machine Learning Mice, Inbred mdx Electromyography Electric Impedance Muscular Dystrophies Disease Models, Animal Muscle, Skeletal
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Deep Learning-Based Image Analysis of Liver Steatosis in Mouse Models.

The American journal of pathology May 24, 2023
The incidence of nonalcoholic fatty liver disease is a continuously growing health problem worldwide, along with obesity. Therefore, novel methods to both efficiently study the manifestation of nonalcoholic fatty liver disease and to analyze drug eff...
Mice Disease Models, Animal Liver Non-alcoholic Fatty Liver Disease Algorithms Animals Deep Learning Neural Networks, Computer
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A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy.

Respiratory research May 9, 2023
Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease progression and response to candidate drugs in various animal models of human disease, but manual image processing is still highly time-consuming and prone to operat...
Mice Disease Models, Animal Bleomycin Animals Deep Learning Pulmonary Fibrosis X-Ray Microtomography Humans Reproducibility of Results
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A pharmacokinetic-pharmacodynamic model based on the SSA-1DCNN-Attention network and the semicompartment method.

Biotechnology & genetic engineering reviews Apr 5, 2023
To solve the problem of inaccurate prediction caused by the lack of representativeness of samples due to the small sample size of the collected clinical data when using machine learning methods to predict drug concentration in plasma and describe the...
Cynanchum Mice Disease Models, Animal Epilepsy Models, Biological Neural Networks, Computer Machine Learning Saponins Algorithms Pharmacokinetics Animals
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Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.

eLife Dec 8, 2022
Mice are the most commonly used model animals for itch research and for development of anti-itch drugs. Most laboratories manually quantify mouse scratching behavior to assess itch intensity. This process is labor-intensive and limits large-scale gen...
Deep Learning Mice Disease Models, Animal Pruritus Injections Behavior, Animal Animals Chloroquine
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3-Dimensional Immunostaining and Automated Deep-Learning Based Analysis of Nerve Degeneration.

International journal of molecular sciences Nov 26, 2022
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease driven by inflammation and demyelination in the brain, spinal cord, and optic nerve. Optic neuritis, characterized by inflammation and demyelination of the optic nerve, is a sympt...
Mice, Inbred C57BL Neurodegenerative Diseases Animals Multiple Sclerosis Inflammation Optic Neuritis Deep Learning Disease Models, Animal Mice Nerve Degeneration Encephalomyelitis, Autoimmune, Experimental
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A fully automated deep learning pipeline for micro-CT-imaging-based densitometry of lung fibrosis murine models.

Respiratory research Nov 11, 2022
Idiopathic pulmonary fibrosis, the archetype of pulmonary fibrosis (PF), is a chronic lung disease of a poor prognosis, characterized by progressively worsening of lung function. Although histology is still the gold standard for PF assessment in prec...
Densitometry X-Ray Microtomography Animals Disease Models, Animal Deep Learning Pulmonary Fibrosis Mice
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Deep learning-based behavioral profiling of rodent stroke recovery.

BMC biology Oct 15, 2022
BACKGROUND: Stroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional motor recovery is considered the primary targeted outcome, tests in rodents are still poorly reprod...
Stroke Brain Ischemia Deep Learning Humans Rodentia Mice Animals Disease Models, Animal
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